Dynamics of Large Random Systems

大型随机系统的动力学

• 批准号: 9112767
• 负责人: Joshua Deutsch
• 金额: $ 18万
• 依托单位: University of California-Santa Cruz
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1995-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9112767&HistoricalAwards=false
• 关键词: Dynamics; Large; Random; Systems

This grant is co-funded between the Materials Theory and the Biophysics programs at NSF. Several topics in condensed matter physics will be investigated. The primary emphasis will be on gel electrophoresis, a topic of great importance in biology and materials processing. The electrophoresis of very long chain polymers such as megabase length DNA is still not well understood. There are still many unexplained experimental effects that greatly reduce the efficacy of this technique. These effects will be explored theoretically in consultation with experimentalists. A newly developed long range Monte Carlo algorithm will be used and will include the effects of gel heterogeneity and intra-chain repulsion. Work will also be undertaken on the effect of polymers on turbulent flow by extending an analytical treatment developed by the principal investigator to more realistic descriptions of the velocity field. Research will also be conducted on novel random matrix ensembles and their connection with the quantum statistical properties of isolated systems. %%% Pulsed-field gel electrophoresis is an experimental technique used to separate DNA molecules containing up to two million base pairs. This discovery was a critical factor in making the human genome project possible. DNA can be viewed as a polymer and the methodology of polymer science can be applied to studies of the behavior of DNA in an electric field. The present grant will continue fundamental and critical studies on theoretical and computational aspects of pulsed-field gel electrophoresis. Such studies help in interpreting the experimental results and in predicting useful behavior of this important technique.

这项赠款是共同资助之间的材料理论和 NSF的生物物理学项目。 凝聚态中的几个问题 物理学将被研究。 主要重点将放在凝胶上 电泳是生物学中一个非常重要的课题， 材料加工 超长链电泳 聚合物如百万倍长度的DNA仍然没有很好地理解。 仍然有许多无法解释的实验效应， 降低了这项技术的效率。 这些影响将是 在理论上与实验学家进行了探讨。 一 新开发的远程蒙特卡罗算法将被使用， 将包括凝胶异质性和链内 排斥 还将开展关于聚合物影响的工作 对湍流的分析处理， 主要研究者对 速度场 研究还将进行新的随机 矩阵系综及其与量子统计的联系 孤立系统的性质。 %%% 脉冲场凝胶电泳是一种实验技术， 来分离含有多达两百万个碱基对的DNA分子。 这一发现是制造人类基因组的关键因素 项目可能。 DNA可以被看作是一种聚合物， 聚合物科学的方法论可以应用于研究 DNA在电场中的行为 目前的补助金将 继续对理论和实践进行基础和批判性研究， 脉冲场凝胶电泳的计算方面。 等 研究有助于解释实验结果， 预测这一重要技术的有用行为。