Small Grants for Exploratory Research: Optical Isomer Resolution by Novel Aqueous Two-Phase Systems

用于探索性研究的小额资助：新型水相两相系统的旋光异构体拆分

• 批准号: 9114499
• 负责人: James Hsu
• 金额: $ 5万
• 依托单位: Lehigh University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-01 至 1993-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9114499&HistoricalAwards=false
• 关键词: Small; Grants; Exploratory; Research; Optical

Many drugs are chiral, that is, they exist in right-and left- handed molecular forms called enantiomers. Although structure is almost identical, enantiomers can differ considerably in their pharmacological effects. For drug development, it is crucial to investigate the pharmacokinetics effects of individual pure enantiomers during preclinical and clinical trials. However, the lack of sufficient quantities of individual stereoisomers drugs for carrying out these trials, and the expensive separation techniques for optical isomer resolution currently represent a bottleneck. The objective of this project is to use a variety of newly discovered novel aqueous two-phase systems for the resolution of optical isomers. Because the phase-forming compounds in these novel aqueous two-phase systems are relatively cheap, they will provide an inexpensive technique by which the chiral separation can be carried out. In order to fully utilize their potential, a fundamental investigation of optical isomer partitioning in these new systems is done with the goal of enhancing the separation factor by varying environmental conditions. This is a Small Grant for Exploratory Research (SGER) jointly supported by the Separation and Purification and the Interfacial, Transport, and Thermodynamics Programs.

许多药物是手性的，也就是说，它们以右旋和左旋的分子形式存在，称为对映体。虽然结构几乎相同，但对映体的药理作用可能会有很大的不同。对于药物开发来说，在临床前和临床试验中研究单个纯对映体的药代动力学效应是至关重要的。然而，缺乏足够数量的单个立体异构体药物来进行这些试验，以及昂贵的光学异构体拆分技术目前是一个瓶颈。本项目的目标是使用各种新发现的新型双水相体系来拆分光学异构体。由于这些新型双水相体系中的成相化合物相对便宜，它们将提供一种廉价的手性分离技术。为了充分利用它们的潜力，对光学异构体在这些新体系中的分配进行了基础研究，目的是通过改变环境条件来提高分离因子。这是一笔小额的探索性研究(SGER)补助金，由分离和纯化以及界面、运输和热力学计划联合支持。