U.S.-Japan Cooperative Research (Photoconversion/Photo- synthesis): The Design and Study of Photoreactive Metal Nitrosyl Complexes

美日合作研究（光转换/光合成）：光反应性金属亚硝酰配合物的设计与研究

• 批准号: 9116346
• 负责人: Peter Ford
• 金额: $ 1.14万
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1996-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9116346&HistoricalAwards=false
• 关键词: U.S.; Japan; Cooperative; Research; Photoconversion

This award will support a two-year U.S.-Japan Cooperative Photoconversion/Photosynthesis Research Program project between Professor Peter Ford, Department of Chemistry, University of California, Santa Barbara, and Dr. Mikio Hoshino, Solar Energy Research Group, The Institute of Physical and Chemical Research (RIKEN), Tokyo, Japan. The project will focus on the investigation of the fundamental chemistry of new metallo-organic compounds that are photochemical precursors to nitric oxide (NO) formation. Nitric oxide is a known cardiovascular dilator recently identified as the endothelium-derived relaxing factor in blood vessels and implicated as having an intercellular messenger role in mammalian neural transmission and in the activation of macrophages to the bactericidal/tumoricidal state. The collaboration will bring together the complementary talents and expertise of two very productive research groups in the United States and Japan to investigate the synthesis and photoreaction behavior of a variety of nitrosyl metal complexes with the long term (speculative) goal of understanding fundamental principles necessary for the design of new photodynamic therapy (PDT) drugs.

该奖项将支持由加州大学圣巴巴拉分校化学系Peter Ford教授和日本东京理化研究所（RIKEN）太阳能研究小组Mikio Hoshino博士共同开展的为期两年的美日合作光转化/光合作用研究项目。该项目将重点研究新型金属有机化合物的基础化学，这些化合物是一氧化氮（NO）形成的光化学前体。一氧化氮是一种已知的心血管扩张剂，最近被发现是血管内皮来源的松弛因子，在哺乳动物神经传递和巨噬细胞激活到杀菌/杀肿瘤状态中具有细胞间信使作用。此次合作将汇集美国和日本两个非常富有成效的研究小组的互补人才和专业知识，研究各种亚硝基金属配合物的合成和光反应行为，其长期（推测）目标是了解设计新型光动力治疗（PDT）药物所需的基本原理。