New Methods for Polyketide Synthesis

本课程将深入探讨N-氨基氮杂环丙烷作为手性辅助剂在肼基烷基化反应和其他反应中的化学作用。化学应允许以高度收敛和对映体选择性的方式制备1，3-跳过的多甲基化碳链。扩展Shapiro类型的消除反应有望产生高效的手性烯烃构筑新方法。该方法学将应用于大内酯抗生素长春新素的合成。有了这个奖项，有机合成计划将支持加州大学欧文分校的A.Richard Chamberlin博士的研究。这项研究探索了手性方法的发展，以合成在重要抗生素家族中发现的重要多元醇和聚丙酸酯结构。这将有利于生物化学和医学以及化学工业的研究。

The chemistry of N-aminoaziridines as chiral auxiliaries in hydrazone alkylations and other reactions will be thoroughly explored. The chemistry should allow the preparation of 1,3-skipped polymethylated carbon chains in a highly convergent and enantioselective manner. Extensions to Shapiro-type elimination reactions promise to result in efficient new methods of chiral alkene construction. The methodology will be applied to the synthesis of the macrolactone antibiotic venturicin. %%% With this award, the Organic Synthesis Program will support the research of Dr. A. Richard Chamberlin at the Unversity of California-Irvine. The research explores the development of chiral methodologies for synthesis of the important polyol and polypropionate structures found in important antibiotic families. This should benefit research in biochemistry and medicine, as well as in the chemical industry.