New Methods for Polyketide Synthesis

N-氨基氮杂环丙烷作为手性助剂的化学 腙烷基化和其他反应将彻底 探讨了 化学反应应允许制备 1，3-跳跃的多甲基化碳链， 和对映体选择性的方式。 Shapiro型的延伸 消除反应有望产生高效的新 手性烯烃的构建方法。 方法将是 应用于大环内酯类抗生素的合成， venturicin。 %%% 有了这个奖项，有机合成计划将支持 A博士的研究理查德·钱伯林（Richard Chamberlin）， 加州-欧文本研究探讨了 合成重要多元醇的手性方法， 在重要抗生素中发现聚丙酸酯结构 家庭 这将有利于生物化学的研究， 医药，以及化学工业。

The chemistry of N-aminoaziridines as chiral auxiliaries in hydrazone alkylations and other reactions will be thoroughly explored. The chemistry should allow the preparation of 1,3-skipped polymethylated carbon chains in a highly convergent and enantioselective manner. Extensions to Shapiro-type elimination reactions promise to result in efficient new methods of chiral alkene construction. The methodology will be applied to the synthesis of the macrolactone antibiotic venturicin. %%% With this award, the Organic Synthesis Program will support the research of Dr. A. Richard Chamberlin at the Unversity of California-Irvine. The research explores the development of chiral methodologies for synthesis of the important polyol and polypropionate structures found in important antibiotic families. This should benefit research in biochemistry and medicine, as well as in the chemical industry.