New Methods for Polyketide Synthesis

n -氨基叠氮嘧啶作为手性助剂在腙烷基化和其他反应中的化学作用将被深入探讨。化学应允许以高度收敛和对映选择性的方式制备1,3跳过的多甲基化碳链。对夏皮罗型消去反应的扩展有望产生有效的手性烯烃构造新方法。该方法将应用于大内酯类抗生素文丘里辛的合成。有了这笔奖金，有机合成计划将支持加州大学欧文分校的A.理查德·钱伯林博士的研究。本研究探索手性方法的发展，以合成重要抗生素家族中发现的重要多元醇和聚丙酸结构。这将有利于生物化学和医学以及化学工业的研究。

The chemistry of N-aminoaziridines as chiral auxiliaries in hydrazone alkylations and other reactions will be thoroughly explored. The chemistry should allow the preparation of 1,3-skipped polymethylated carbon chains in a highly convergent and enantioselective manner. Extensions to Shapiro-type elimination reactions promise to result in efficient new methods of chiral alkene construction. The methodology will be applied to the synthesis of the macrolactone antibiotic venturicin. %%% With this award, the Organic Synthesis Program will support the research of Dr. A. Richard Chamberlin at the Unversity of California-Irvine. The research explores the development of chiral methodologies for synthesis of the important polyol and polypropionate structures found in important antibiotic families. This should benefit research in biochemistry and medicine, as well as in the chemical industry.