Purchase of an API-HPLC Mass Spectrometer

购买 API-HPLC 质谱仪

• 批准号: 9709131
• 负责人: A. Richard Chamberlin
• 金额: $ 16.33万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9709131&HistoricalAwards=false
• 关键词: Purchase; API; HPLC; Mass; Spectrometer

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will assist the Department of Chemistry at University of California at Irvine to acquire a atmospheric pressure ionization (API) quadrupole mass spectrometer. This equipment will enhance research in a number of areas including the following: (1)synthesis and integration of non-natural amino acids into peptides and proteins for fundamental structure/function studies, (2) polyguanidinium/polyamine containing alkaloids, (3) structural determinations on macrolide antibiotics, (4) oligonucleotides and synthetic ionomers, and (5) dearomatization reactions of amino aids, peptides and in indolocarbazole glycoside synthesis. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to proteins and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest techniques available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.

这项来自化学研究仪器和设施(CRIF)计划的奖项将帮助加州大学欧文分校化学系获得大气压电离(API)四极质谱计。该设备将加强以下领域的研究：(1)用于基础结构/功能研究的非天然氨基酸的合成和整合成多肽和蛋白质；(2)含有生物碱的聚鸟苷/多胺；(3)大环内酯类抗生素的结构测定；(4)寡核苷酸和合成离聚体；(5)氨基辅助剂、多肽和吲哚咔唑糖苷合成中的脱芳构化反应。质谱仪(MS)是一种用于探测大量有机、生物有机和有机金属分子的内部结构细节和获得其分子组成的技术。电喷雾技术的加入将MS的范围扩展到蛋白质和核酸的相对分子质量，远远超过了任何其他技术。电喷雾电离与高分辨率相结合的使用提供了质谱学中可用的最新技术。它为化学家提供了表征化合物的最强大的工具之一。在质谱学中获得这种能力对于开展许多化学领域的前沿研究是至关重要的。