Development and Application of X-Ray Absorption Spectroscopy to Study Structure in Biological and Chemical Systems

X射线吸收光谱法在生物和化学系统结构研究中的发展和应用

• 批准号: 9121576
• 负责人: Keith Hodgson
• 金额: $ 28.53万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-02-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9121576&HistoricalAwards=false
• 关键词: Development; Application; Ray; Absorption; Spectroscopy

In this project, jointly funded by the Physical Chemistry and Biophysics Programs, X-ray absorption techniques for high resolution studies of metal ion centers in biologically important molecules will be developed. Specific attention will be paid to developing direct probes of covalence in iron- and copper-containing proteins. %%% Nitrogenase, the enzyme responsible for converting atmospheric nitrogen to ammonia, is one of nature's major sources of fertilizer. Detailed chemical understanding of the biological process by which this conversion is accomplished brings us closer to the goal of economical and environmentally benign fertilizer production. This project, by developing X-ray methods of determining structure and bonding in the relevant enzymes, may lead to major breakthroughs in this effort.

在这个项目中，由物理化学和 生物物理程序，X射线吸收技术，高 生物体内金属离子中心的分辨研究 重要的分子将被开发出来。 具体注意事项将 致力于开发铁中共价的直接探针， 含铜蛋白质 %%% 固氮酶，负责将大气中的 氮转化为氨，是自然界中 肥料详细了解生物化学 完成这种转换的过程使我们 更接近经济和环境友好的目标 化肥生产。这个项目通过开发X射线 确定相关材料中结构和键合的方法 酶，可能会导致这一努力的重大突破。