U.S.-Japan Cooperative Science: Development of X-ray CCD Detectors and their Applications to Synchrotron Radiation Time-resolved Solution Scattering

小行星9513129 该奖项支持斯坦福大学的基思霍奇森博士和日本筑波高能物理国家实验室的Yoshiyuki Amemiya博士之间为期三年的合作研究项目。 本计画是一个利用同步辐射进行时间解析、小角X光散射的合作仪器发展计画。 新的仪器将被应用于选定的合作研究项目的蛋白质折叠和变构转换。 该研究计划的主要方面是：（1）参与联合开发用于SAXS研究的先进CCD探测器; 2）合作开发技术，以研究更快时间域中的结构变化（低至约1 ms），利用日本光子工厂的这些发展，然后在斯坦福大学同步辐射实验室（SSRL）的超高通量光束线上进行生物系统的实际结构研究。 美国研究人员将通过参与日本先进X射线探测器系统的开发而受益匪浅，而日本合作者将在SSRL获得新的合成多层单色器的经验。 该提案实现了该计划的目标，共同奋进将两国的最先进方法纳入国际合作努力。 ***

9513129 Hodgson This award supports a three year cooperative research project between Dr. Keith Hodgson of Stanford University and Dr. Yoshiyuki Amemiya of the National Laboratory for High Energy Physics in Tsukuba, Japan. This project represents a program of cooperative instrument development for time- resolved solution, small-angle x-ray scattering (SAXS) using synchrotron radiation. The new instrumentation will be applied to selected collaborative research projects on protein folding and allosteric transitions. The principal aspects of the research plan are 1) to participate in the joint development of advanced CCD-based detectors for SAXS studies; 2) to collaborate on the development of techniques to investigate structural changes in a faster time domain (down to about 1 ms) than currently utilized, and 3) to utilize these developments at the Photon Factory in Japan and then on an ultra high flux beam line at the Stanford Synchrotron radiation Laboratory (SSRL) for actual structural studies of biological systems. The U.S. investigators will benefit significantly by participating in the development of advanced x-ray detector systems in Japan whereas the Japanese collaborators will gain experience with the new synthetic multilayer monochromator at SSRL. This proposal fulfills the objectives of the Program in its joint endeavor bringing state of the art methods from two countries into a joint international collaborative effort. ***