Acquisition of X-ray Absorption Spectroscopy to Study Structure in Biological and Chemical Systems

该奖项为斯坦福大学同步加速器研究实验室（SSRL）购买仪器提供资金。该设备将促进数据收集和分析，使可以进行的实验数量和类型显著增加，并将最大限度地利用SSRL最近在同步辐射质量和可用性方面的改进所带来的好处。在原子水平上对蛋白质结构和功能的理解的快速增长，在很大程度上是由于用于酶和其他蛋白质的x射线晶体学分析的计算工具和硬件的发展和完善。特别是，使用同步加速器作为x射线源，可以研究病毒的结构和其他难以接近的非常大的蛋白质结构。最近同步加速器设计和用于数据收集和还原的设备的改进使曾经困难的研究变得常规，并使研究酶机制的新路线成为可能。购买的设备将为使用SSRL的研究界所有部门的大量研究人员提供这一进展的好处。

This award provides funds to Stanford University for the purchase of instrumentation for the Stanford Synchrotron Research Laboratory (SSRL). The equipment will facilitate data collection and analysis, allowing a significant increase in the number and types of experiments that can be performed, and will maximize the benefits to be gained from the recent improvement in quality and availability of synchrotron radiation at SSRL. The rapid growth in the understanding of the structure and function of proteins at the atomic level has resulted in large part through the development and perfection of computational tools and hardware used for X-ray crystallographic analysis of enzymes and other proteins. The use of synchrotrons as X-ray sources has, in particular, allowed the investigation of the structure of viruses and other very large protein structures that are otherwise inaccessible. Recent improvements in synchrotron design and in the equipment used for data collection and reduction has made once difficult investigations routine and has made new lines of investigation into enzyme mechanism possible. The equipment being purchased will provide the benefits of this progress to a large number of investigators from all sectors of the research community who use the SSRL.