Acquisition of X-ray Absorption Spectroscopy to Study Structure in Biological and Chemical Systems

获取 X 射线吸收光谱来研究生物和化学系统的结构

• 批准号: 9122609
• 负责人: Keith Hodgson
• 金额: $ 23.44万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-12-01 至 1994-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9122609&HistoricalAwards=false
• 关键词: Acquisition; ray; Absorption; Spectroscopy; Study

This award provides funds to Stanford University for the purchase of instrumentation for the Stanford Synchrotron Research Laboratory (SSRL). The equipment will facilitate data collection and analysis, allowing a significant increase in the number and types of experiments that can be performed, and will maximize the benefits to be gained from the recent improvement in quality and availability of synchrotron radiation at SSRL. The rapid growth in the understanding of the structure and function of proteins at the atomic level has resulted in large part through the development and perfection of computational tools and hardware used for X-ray crystallographic analysis of enzymes and other proteins. The use of synchrotrons as X-ray sources has, in particular, allowed the investigation of the structure of viruses and other very large protein structures that are otherwise inaccessible. Recent improvements in synchrotron design and in the equipment used for data collection and reduction has made once difficult investigations routine and has made new lines of investigation into enzyme mechanism possible. The equipment being purchased will provide the benefits of this progress to a large number of investigators from all sectors of the research community who use the SSRL.

该奖项为斯坦福大学提供资金， 为斯坦福大学同步加速器研究购买仪器 实验室（SSRL）。 该设备将有助于数据收集 和分析，使数量大幅增加， 可以进行的实验类型，并将最大限度地提高 从最近的质量改进中获得的好处， 同步辐射的可用性。 对结构的理解的快速增长， 蛋白质在原子水平上的功能在很大程度上导致了 通过计算工具的发展和完善， 用于酶的X射线晶体学分析的硬件， 其他蛋白质。 使用同步加速器作为X射线源， 特别是，允许调查病毒的结构 和其他非常大的蛋白质结构， 难以接近 同步加速器设计和 用于数据收集和整理的设备已经完成一次 困难的调查是例行公事， 酶机制研究成为可能。 的装备 购买将提供这一进展的好处，以一个大的 来自研究界所有部门的调查员人数 使用SSRL的人