Acquisition of a Triple Quadrupole Mass Spectrometer

购置三重四极杆质谱仪

• 批准号: 9201814
• 负责人: I. Jonathan Amster
• 金额: $ 19.83万
• 依托单位: University of Georgia Research Foundation Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-15 至 1995-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9201814&HistoricalAwards=false
• 关键词: Acquisition; Triple; Quadrupole; Mass; Spectrometer

9201814 Amster Funds are requested for the purchase an extended mass range triple quadrupole mass spectrometer. This instrument will used by investigators in the Departments of Chemistry and Biochemistry to determine the molecular weights of peptides and proteins with sizes in the range 1,000-100,000 Da, the primary structures of proteins, and the number and location of metal atoms in native and modified proteins. The requested spectrometer will facilitate characterization of transforming growth factor E, pyridoxal-5' phosphate binding sites, biological electron transfer pathways, and a range of native and mutated metalloenzymes and metalloproteins. The proposed instrument will be used for training and research directly related to the NSF research training group in the role of transition metals in biology at the University of Georgia.

9201814需要AMSTER资金购买一台扩大质量范围的三重四极质谱计。这台仪器将被化学和生物化学系的研究人员用来测定1000-10万Da范围内的多肽和蛋白质的相对分子质量，蛋白质的一级结构，以及天然和修饰蛋白质中金属原子的数量和位置。所需的光谱仪将有助于表征转化生长因子E、吡哆醛-5‘磷酸结合部位、生物电子转移途径以及一系列天然和突变的金属酶和金属蛋白。拟议的仪器将用于与乔治亚大学国家科学基金会研究培训小组在过渡金属在生物学中的作用直接相关的培训和研究。