Acquisition of a Fourier Transform Mass Spectrometer and Development of New Techniques for Biopolymer Analysis

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Mass spectrometry has become one of the most powerful tools for measuring molecular weights of peptides and proteins, and for determining their primary structures. Thus mass spectrometry is of central importance to biotechnology, biochemistry, and biological research. Fourier transform mass spectrometry is emerging as the premier high- performance mass spectrometer for the analysis of biological compounds. This proposal seeks funding to advance the development of several high-performance capabilities of Fourier transform mass spectrometry for peptide and protein analysis, and to make these readily available in a commercial mass spectrometer. This project will be a joint effort between the P.I. and Bruker Instruments, Inc., a manufacturer of a commercial Fourier transform mass spectrometer. The requested funds will be used to purchase a Fourier transform mass spectrometer from Bruker Instruments. Hardware, software, and technique developments will be pursued jointly by the P.I. and Bruker Instruments. In addition to the development efforts, this instrument will also be used to support the research and training programs of members of the Center for Metalloenzyme Studies, a NSF supported Research Training Group at the University of Georgia.