Chemical Ionization of Laser Desorbed Peptides in a Fourier Transform Mass Spectrometer

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This research, supported by the Analytical and Surface Chemistry Program in the Chemistry Division, will investigate ways to determine the sequence of fundamental building blocks of small proteins using a variant of mass spectrometry. Potential applications include diagnosis of some genetic diseases, and monitoring of metabolic irregularities. %%% Research, supported by the Analytical and Surface Chemistry Program in the Chemistry Division, will use laser desorption mass spectrometry and collision-induced dissociation to study the fragmentation of vaporized peptides. Fourier Transform mass spectrometry will allow many sequential collision/measurement cycles, so that one may step-wise decompose the peptides. Both atomic and molecular collision species will be tested.