Craniofacial Development in Eutherian and Metatherian Mammals

真兽类和后兽类哺乳动物的颅面发育

• 批准号: 9208514
• 负责人: Kathleen Smith
• 金额: $ 2万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-01 至 1994-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9208514&HistoricalAwards=false
• 关键词: Craniofacial; Development; Eutherian; Metatherian; Mammals

Work supported on a previous NSF grant has demonstrated that the development of craniofacial systems in placental and marsupial mammals is characterized by large scale changes in relative rate and timing. Specifically, the development of the central nervous system and skeletal system are both dramatically slowed in metatherians relative to eutherians, however, the development of the muscular system is greatly accelerated. These results confirm hypotheses that suggest metatherians possess specific developmental adaptations to the requirements of their life history and suggest, somewhat surprisingly, that the development of craniofacial systems is quite plastic. In the current project these results will be extended in two major directions. First, craniofacial development will be examined in other mammalian species to ask whether the variation is limited to characterizing the two largest mammalian groups, eutherians and metatherians. Second, preliminary studies on the cellular and molecular bases of the developmental patterns observed will be initiated and the development of the nervous system will be examined in detail. This study will combine comparative information with data on gross, histological, cellular and molecular processes to allow an integrated approach to craniofacial development. The results obtained will address specific and significant problems on mammalian biodiversity and provide opportunities to examine the mechanisms of and constraints on developmental patterns.

以前NSF资助的工作已经证明， 颅面系统在胎盘和 有袋类哺乳动物的特点是大规模的变化， 相对速率和时间。 具体而言，发展 中枢神经系统和骨骼系统 然而，相对于真兽目， 肌肉系统的发育大大加快。 这些 研究结果证实了假设， 具体的发展适应其要求 生活史，并提出，有点令人惊讶的是， 颅面系统的发育是相当可塑的。 在 目前，这些成果将在两个主要领域得到推广。 方向 首先，颅面发育将在 其他哺乳动物物种来询问变异是否有限 两个最大的哺乳动物群体真兽目 和元兽。 第二，对细胞的初步研究 观察到的发育模式的分子基础 神经系统的发展将是 详细检查。 这项研究将联合收割机的比较资料与下列数据结合起来： 大体、组织学、细胞和分子过程， 颅面发育的综合方法。 结果 获得将解决具体和重大的问题， 哺乳动物的生物多样性，并提供机会， 发展模式的机制和制约因素。