Combinatorial Synthesis and Screening of Important Classes of Organic Compounds

重要一类有机化合物的组合合成与筛选

• 批准号: 9220971
• 负责人: Jonathan Ellman
• 金额: $ 3.2万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-15 至 1993-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9220971&HistoricalAwards=false
• 关键词: Combinatorial; Synthesis; Screening; Important; Classes

This award is the starter grant increment of Dr. Ellman's Postdoctoral Fellowship in Chemistry. The work will develop methods of combinatorial synthesis of organic compounds which may have physiological activity. The approach of combinatorial sythesis is important because it can lead to very many more compounds than the current "one at a time" methods. This becomes particularly useful when systematically related derivatives are desired. The work to be done will lead to benzodiazepines from the acylation or alkylation of amino benzophenones in microtiter plates. Methods will be developed to produce libraries of more complex products. %%% Currently, synthetic methods are limited by the fact that they produce one compound at a time. This work will lead to the simultaneous production of many related compounds. Development of the methods to be studied can lead to much more efficient and less expensive approaches to important drugs for human diseases.

这个奖项是埃尔曼博士的启动补助金增量 化学博士后奖学金。这项工作将发展 有机化合物的组合合成方法， 可能具有生理活性。组合方法 合成是重要的，因为它可以导致更多的 与目前的“一次一个”方法相比，这 当系统地将 衍生物是需要的。要做的工作将导致 来自氨基的酰化或烷基化的苯并二氮杂 微量滴定板中的二苯甲酮。将制定方法 to produce生产libraries图书馆of more complex复杂products产品. %%% 目前，合成方法受到以下事实的限制： 一次只能产生一种化合物这项工作将导致 同时生产多种相关化合物。发展 的方法来研究可以导致更有效的 和更便宜的方法来获得重要的药物， 疾病