Asymmetric Synthesis of Amines

胺的不对称合成

• 批准号: 0742565
• 负责人: Jonathan Ellman
• 金额: $ 45万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2010-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0742565&HistoricalAwards=false
• 关键词: Asymmetric; Synthesis; Amines

This project will continue work on the development of methods for the asymmetric synthesis of amine-containing compounds. Many of the proposed methods rely on tert-butanesulfinamide, which serves as a chiral amine reagent for some transformations and as a key chiral element embedded in organocatalysts for other transformations. Rhodium-based asymmetric catalysts will also be utilized to develop practical methods for the enantioselective catalytic synthesis of alpha-branched amines. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Jonathan A. Ellman of the Department of Chemistry at the University of California at Berkeley. Professor Ellman's research efforts are centered on the development of practical and efficient methods for the asymmetric synthesis of amines because a very high percentage of drugs, biopharmaceuticals, and agrochemicals incorporate chiral amines. Based upon the very real impact of prior efforts from his laboratory, the successful development of the proposed methodology will contribute to the discovery and production of new products with societal benefits by the pharmaceutical, biotechnology, and agrochemical industries.

该项目将继续致力于开发含胺化合物的不对称合成方法。 许多提出的方法依赖于叔丁亚磺酰胺，它在某些转化中充当手性胺试剂，并在其他转化中充当嵌入有机催化剂中的关键手性元素。铑基不对称催化剂还将用于开发对映选择性催化合成α-支化胺的实用方法。 有机与高分子化学项目通过该奖项支持加州大学伯克利分校化学系 Jonathan A. Ellman 教授的研究。 埃尔曼教授的研究工作集中在开发实用且有效的胺不对称合成方法，因为很大比例的药物、生物制药和农用化学品都含有手性胺。 基于他的实验室先前努力的实际影响，所提出的方法的成功开发将有助于制药、生物技术和农化行业发现和生产具有社会效益的新产品。