Applications of Sulfonamides and Sulfinamides to Small Molecule Library Synthesis

磺胺类和亚磺酰胺类药物在小分子文库合成中的应用

• 批准号: 9807477
• 负责人: Jonathan Ellman
• 金额: $ 30万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9807477&HistoricalAwards=false
• 关键词: Applications; Sulfonamides; Sulfinamides; Small; Molecule

The research proposed involves the development of methods for the synthesis of small molecule libraries based on solid supports. In earlier NSF supported work, an N-acylsulfonamide linker was developed which allowed chemoselectively activated nucleophilic release of library members in a final step. This development will now be extended to libraries incorporating amino acids and peptides. Stereochemicaly defined compounds will be generated both by linking optically active building blocks and by synthesizing asymmetric centers on the solid supports. With this renewal award, the Organic and Macromolecular Chemistry Program is continuing support for the research of Dr. Jonathan A. Ellman in the Department of Chemistry at the University of California at Berkeley. The research focuses on developing improved combinatorial methods for the synthesis of libraries of small molecules which can be useful in the fields of drug discovery, molecular recognition, materials development, and catalysis. Graduate students will receive valuable training in organic synthesis and combinatorial chemistry, which will prepare them for careers in several rapidly growing industries.

拟议的研究涉及开发方法， 基于固体支持物的小分子文库的合成。 在 在NSF支持的早期工作中，开发了一种N-酰基磺酰胺连接体 其允许文库的化学选择性活化亲核释放 成员在最后一步。 这一发展现在将扩大到 包含氨基酸和肽的文库。 立体化学 将通过连接光学活性的 通过在固体上合成不对称中心 支持. 有了这个更新奖，有机和高分子 化学计划继续支持乔纳森博士的研究 A.加州大学化学系的埃尔曼说， 在伯克利。 研究重点是开发改进的组合 用于合成小分子文库的方法， 可用于药物发现、分子识别、材料 发展和催化。 研究生将获得宝贵的 有机合成和组合化学培训，这将 为他们在几个快速发展的行业的职业生涯做好准备。