Asymmetric Synthesis of Amines

胺的不对称合成

• 批准号: 1043136
• 负责人: Jonathan Ellman
• 金额: $ 8.81万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1043136&HistoricalAwards=false
• 关键词: Asymmetric; Synthesis; Amines

This project will continue work on the development of methods for the asymmetric synthesis of amine-containing compounds. Many of the proposed methods rely on tert-butanesulfinamide, which serves as a chiral amine reagent for some transformations and as a key chiral element embedded in organocatalysts for other transformations. Rhodium-based asymmetric catalysts will also be utilized to develop practical methods for the enantioselective catalytic synthesis of alpha-branched amines. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Jonathan A. Ellman of the Department of Chemistry at the University of California at Berkeley. Professor Ellman's research efforts are centered on the development of practical and efficient methods for the asymmetric synthesis of amines because a very high percentage of drugs, biopharmaceuticals, and agrochemicals incorporate chiral amines. Based upon the very real impact of prior efforts from his laboratory, the successful development of the proposed methodology will contribute to the discovery and production of new products with societal benefits by the pharmaceutical, biotechnology, and agrochemical industries.

本项目将继续致力于开发含胺化合物的不对称合成方法。 许多所提出的方法依赖于叔丁基亚磺酰胺，其作为手性胺试剂用于某些转化，并作为嵌入有机催化剂中的关键手性元素用于其他转化。铑基不对称催化剂也将用于开发α-支链胺的对映选择性催化合成的实用方法。 有了这个奖项，有机和高分子化学计划是支持乔纳森教授的研究。他是加州大学伯克利分校化学系的Ellman博士。 Ellman教授的研究工作集中在胺的不对称合成的实用和有效的方法的开发上，因为药物，生物制药和农用化学品的比例非常高。 基于他的实验室先前努力的非常真实的影响，所提出的方法的成功开发将有助于制药、生物技术和农用化学工业发现和生产具有社会效益的新产品。