Asymmetric Synthesis of Amines

该项目将继续开发不对称合成胺类化合物的方法。许多已提出的方法依赖于叔丁基磺酰胺，它在某些转化中作为手性胺试剂，在其他转化中作为关键的手性元素嵌入有机催化剂中。我们还将利用不对称催化剂来开发α-支化胺的对映选择性催化合成的实用方法。通过这一奖项，有机和高分子化学项目支持加州大学伯克利分校化学系乔纳森·A·埃尔曼教授的研究。埃尔曼教授的研究工作集中在开发实用而有效的胺不对称合成方法上，因为药物、生物制药和农用化学品中有很高比例的手性胺。基于他的实验室以前的努力产生的非常真实的影响，拟议方法的成功开发将有助于制药、生物技术和农化行业发现和生产具有社会效益的新产品。

This project will continue work on the development of methods for the asymmetric synthesis of amine-containing compounds. Many of the proposed methods rely on tert-butanesulfinamide, which serves as a chiral amine reagent for some transformations and as a key chiral element embedded in organocatalysts for other transformations. Rhodium-based asymmetric catalysts will also be utilized to develop practical methods for the enantioselective catalytic synthesis of alpha-branched amines. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Jonathan A. Ellman of the Department of Chemistry at the University of California at Berkeley. Professor Ellman's research efforts are centered on the development of practical and efficient methods for the asymmetric synthesis of amines because a very high percentage of drugs, biopharmaceuticals, and agrochemicals incorporate chiral amines. Based upon the very real impact of prior efforts from his laboratory, the successful development of the proposed methodology will contribute to the discovery and production of new products with societal benefits by the pharmaceutical, biotechnology, and agrochemical industries.