NSF Young Investigator: Synthesis of Organic Molecules on Solid Supports

9357134 Ellman本研究的重点是使用固相合成方法同时和组合合成1，4-苯并二氮杂卓、三尖杉酯碱和β-转角模拟物。 然后将针对特定受体或酶筛选所得化合物，以深入了解结构与识别。 该技术的速度可能会使进行此类分析的容易程度发生革命性变化。 有了这个NSF青年研究者奖，合成有机计划正在支持乔纳森·A。加州大学伯克利分校化学系的埃尔曼说。 Ellman博士将把工作重点放在固体支持物上重要类别的非聚合有机化合物库的同时和组合合成上。 然后将针对特定受体或酶筛选化合物，以获得结构与识别信息。 ***

9357134 Ellman The focus of this research is the simultaneous and combinatorial synthesis of 1,4-benzodiazepines, prostaglandins and beta-turn mimics using solid-phase synthetic methodology. The resulting compounds will then be screened against specific receptors or enzymes to gain insight into structure versus recognition. The speed of the technique could revolutionize the ease of carrying out such analyses. %%% With this NSF Young Investigator award, the Synthetic Organic Program is supporting the research of Dr. Jonathan A. Ellman of the Department of Chemistry at the University of California, Berkeley. Dr. Ellman will focus his work on the simultaneous and combinatorial synthesis of libraries of important classes of nonpolymeric organic compounds on solid support. The compounds will then be screened against specific receptors or enzymes to obtain structure versus recognition information. ***