Synthesis of Ligands to Control Catalyst Homogeneity and Miscibility

本研究的重点是利用配体来控制催化剂的均一性和可混性。首先，将制备具有与温度相反的溶解度的聚合物配体。其目标是使用大分子配体来连接金属和调节反应。其次，低聚配体将被设计成提供或促进催化剂周围的溶剂微环境，从而减轻主体溶剂的影响。第三，将研究大分子在公共溶剂中将可溶物质彼此相分离的能力。最后，我们将研究提高立体选择性的手性大分子配体。有了这个奖项，合成有机计划将支持德克萨斯农工大学化学系的David E.Bergbreiter博士的研究。Bergbreiter教授将专注于利用可溶大分子的性质来设计控制均相催化剂物理性质的配位体。一般的想法是了解可溶聚合物的物理化学性质是否能够以有效的方式控制均相催化剂的均质性和可混性。

The focus of this research is the use of ligands to control catalyst homogeneity and miscibility. First, polymeric ligands will be prepared that have inverse temperature dependent solubility. The goal is to use a macromolecular ligand to both ligate a metal and to regulate a reaction. Second, oligomeric ligands will be designed to provide or contribute to the solvent microenvironment around a catalyst so that the effects of bulk solvent are mitigated. Third, macromolecules will be studied for the ability to phase isolate soluble species from one another in a common solvent. Finally, chiral macromolecular ligands that enhance stereoselectivity will be studied. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. David E. Bergbreiter of the Department of Chemistry at Texas A&M University. Professor Bergbreiter will focus his work on using the properties of soluble macromolecules to design ligands that control the physical properties of homogeneous catalysts. The general idea is to learn if the physiochemical properties of soluble polymers can control a homogeneous catalyst's homogeneity and miscibility in useful ways.