New Syntheses of Hyperbranched Ultrathin Grafts

超支化超薄移植物的新合成

• 批准号: 0348477
• 负责人: David Bergbreiter
• 金额: $ 34.5万
• 依托单位: Texas A&M Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0348477&HistoricalAwards=false
• 关键词: New; Syntheses; Hyperbranched; Ultrathin; Grafts

This proposal will employ nonspecific molecular recognition, responsive surfaces and polyvalency to make grafting faster and more efficient. The chemistry will employ graft-on-a-graft chemistry to prepared functional, ultrathin, hyperbranched grafts on both organic and inorganic substrates. The functional interfaces to be prepared will all be assembled with covalent bonds. These covalent assemblies will be derived from known reactions - condensation reactions like amidation and catalytic reactions like triazole formation from alkynes and azides. Such grafts will contain functional groups that can be further modified with spectroscopic probes and the interfaces so formed will be useful in modification of the physical and chemical properties of common materials like polyolefins and metal oxides. The intellectual impact of this proposal is that it will demonstrate ways to use the known advantages of polyvalency, the principles of molecular recognition and the responsive character of macromolecular systems in a useful synthetic way. The proposed work will use weak intermolecular interactions like hydrogen bonding to localize reagents and catalysts at interfaces. Such localization of reagents will facilitate grafting by increasing the relative concentrations of the reagents involved in bond formation. Such effects will make grafting simpler, more practical and less wasteful in terms of reagents. If successful, this research will lead to functional surfaces can be designed so as to intelligently facilitate their own grafting. The broader impact of this proposal is its effect on the scientific training and education of students at both the undergraduate and graduate level. Typically 2-3 undergraduates from Texas A&M and outside will be involved each year, some in the summer and some during the school year. These undergraduates will work side-by-side with 2-3 graduate students. All students will have individual and creative roles in the research and all will participate in publications and presentations at local, regional and national meetings.

该方案将采用非特异性分子识别、反应表面和多价，使接枝更快、更有效。化学将采用接枝对接枝化学在有机和无机底物上制备功能，超薄，超支化的接枝。所制备的功能界面都是用共价键组装的。这些共价组合将来自于已知的反应，如酰胺化反应和催化反应，如炔烃和叠氮化物形成三唑。这种接枝将包含可以用光谱探针进一步修饰的官能团，这样形成的界面将有助于修饰聚烯烃和金属氧化物等普通材料的物理和化学性质。这一建议的智力影响在于，它将展示如何利用多价的已知优势，分子识别原理和大分子系统的响应特性，以一种有用的合成方式。提出的工作将使用弱分子间相互作用，如氢键来定位界面上的试剂和催化剂。这种试剂的定位将通过增加参与成键的试剂的相对浓度来促进接枝。这样的效果将使接枝更简单，更实用，在试剂方面更少浪费。如果成功，本研究将导致功能表面可以被设计，从而智能地方便自身嫁接。这项建议的更广泛的影响是它对本科生和研究生的科学培训和教育的影响。通常情况下，每年会有2-3名来自德州农工大学和校外的本科生参与其中，一些在夏季，一些在学年。这些本科生将与2-3名研究生并肩工作。所有学生都将在研究中发挥个人和创造性的作用，所有学生都将参加地方、区域和国家会议的出版物和演讲。