New Soluble Polymer Supports for Synthesis and Catalysis

用于合成和催化的新型可溶性聚合物载体

• 批准号: 9707710
• 负责人: David Bergbreiter
• 金额: $ 33万
• 依托单位: Texas A&M Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9707710&HistoricalAwards=false
• 关键词: New; Soluble; Polymer; Supports; Synthesis

The focus of this research is to examine poly(N-isopropylacrylamide)co- and terpolymers as supports in catalysis and synthesis. Theses studies will probe the reactivity of soluble polymer-bound species to enzymatic reagents and the feasibility of multistep `Merrifield-like` syntheses on supports that are recovered by thermal precipitation. If successful, this chemistry will lead to alternatives to conventional crosslinked supports. Various catalytic systems that use biphasic polymers will also be developed. These include fluorous phase polymers and polymers with controllable hydrocarbon/water solubility. With this renewal award, the Synthetic Organic Program is supporting the research of Dr. David E. Bergbreiter of the Department of Chemistry at Texas A & M University. Professor Bergbreiter will focus his work on new approaches to the use of soluble polymers as supports for catalysis. The polymers described can, by design, be readily prepared by people with little or no polymer chemistry experience.

本研究的重点是研究聚（N-异丙基丙烯酰胺）co-， 和三元共聚物作为催化和合成的载体。 论文研究 将探测可溶性聚合物结合的物质对酶的反应性 试剂和多步“Merrifield样”合成的可行性， 通过热沉淀回收的载体。 如果成功， 这种化学反应将导致常规交联的替代物， 支持. 使用双相聚合物的各种催化体系将 也要发展。 这些包括氟相聚合物和聚合物 具有可控的烃/水溶解度。 有了这个更新奖， 有机合成项目正在支持大卫博士的研究。 德克萨斯农工大学化学系的Bergbreiter说。 Bergbreiter教授将把他的工作重点放在使用 可溶性聚合物作为催化剂载体。 所述聚合物可以， 通过设计，人们可以很容易地用很少或没有聚合物来制备 化学经验