New Soluble Polymer Supports for Synthesis and Catalysis

本研究的重点是考察聚（n -异丙基丙烯酰胺）共聚物和三元共聚物在催化和合成中的支持作用。这些研究将探讨可溶性聚合物结合物对酶试剂的反应性，以及在热沉淀回收的载体上进行多步“梅里菲尔德式”合成的可行性。如果成功，这种化学反应将成为传统交联支撑的替代品。各种使用双相聚合物的催化系统也将被开发出来。这些包括含氟相聚合物和具有可控烃/水溶解度的聚合物。有了这个更新奖，合成有机项目支持了德克萨斯农工大学化学系的大卫·e·伯格布雷特博士的研究。伯格布雷特教授将把他的工作重点放在利用可溶性聚合物作为催化支撑的新方法上。通过设计，所描述的聚合物可以很容易地由很少或没有聚合物化学经验的人制备。

The focus of this research is to examine poly(N-isopropylacrylamide)co- and terpolymers as supports in catalysis and synthesis. Theses studies will probe the reactivity of soluble polymer-bound species to enzymatic reagents and the feasibility of multistep `Merrifield-like` syntheses on supports that are recovered by thermal precipitation. If successful, this chemistry will lead to alternatives to conventional crosslinked supports. Various catalytic systems that use biphasic polymers will also be developed. These include fluorous phase polymers and polymers with controllable hydrocarbon/water solubility. With this renewal award, the Synthetic Organic Program is supporting the research of Dr. David E. Bergbreiter of the Department of Chemistry at Texas A & M University. Professor Bergbreiter will focus his work on new approaches to the use of soluble polymers as supports for catalysis. The polymers described can, by design, be readily prepared by people with little or no polymer chemistry experience.