Acquisition of an EPR Spectrometer

购买 EPR 光谱仪

• 批准号: 9222752
• 负责人: Frederick Greenaway
• 金额: $ 13.31万
• 依托单位: Clark University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9222752&HistoricalAwards=false
• 关键词: Acquisition; EPR; Spectrometer

9222752 Greenaway The purchase of a multi-institutional, multi-user EPR spectrometer to be housed in the Department of Chemistry at Clark University will complement the Worcester Consortium Center for Magnetic Resonance, located in the same building, to provide facilities for biological and chemical research for institutions throughout Central New England. A total of ten educational institutions throughout New England are represented. Five specific research projects of biomedical emphasis and three of physico-chemical emphasis are proposed, as well as a number of secondary projects. The major users propose studies of: the structure and mechanism of action of lysyl oxidase and related copper-containing amine oxidases; the structures and mechanisms regulating selection and transfer of fragments of antigenic proteins into the antigen- binding sites of major histocompatibility complex molecules; the improvement of EPR dosimetric techniques with emphasis on the use of bone marrow and bone fragments as in situ dosimeters; the cytochrome P-450 monooxygenase-mediated mechanisms of toxicity of chlorocarbons; the effects of metal-binding in the neurochemically- important protein calmodulin on conformation and interactions with intracellular target enzymes and inhibitor proteins; the low-temperature magnetic properties of transparent bimetallic layered ferrimagnetic systems; the nature of the radical sulfur species present in aqueous solutions and at electrode surfaces; quantum effects n linear antiferromagnetic chains.

9222752 Greenaway购买一个多机构，多用户EPR光谱仪将被安置在化学系在克拉克大学将补充伍斯特财团中心磁共振，位于同一建筑物，提供生物和化学研究的设施，为整个中央新英格兰的机构。 整个新英格兰共有10所教育机构参加。 提出了五个生物医学重点的具体研究项目和三个物理化学重点的研究项目，以及一些二级项目。主要用户建议研究： 赖氨酰氧化酶和相关的含铜胺氧化酶的结构和作用机制;调节抗原蛋白片段选择和转移到主要组织相容性复合物分子的抗原结合位点的结构和机制; EPR剂量测定技术的改进，重点是使用骨髓和骨碎片作为原位剂量计;细胞色素P-450单加氧酶介导的氯碳化合物毒性机制;在神经化学上重要的蛋白质钙调蛋白中金属结合对构象和与细胞内靶酶和抑制剂蛋白质的相互作用的影响;透明双层铁磁系统的低温磁性;水溶液和电极表面存在的自由基硫物种的性质;线性反铁磁链的量子效应。