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MRI: Acquisition of a Pulsed Electron Paramagnetic Resonance (EPR) Spectrometer

MRI：脉冲电子顺磁共振 (EPR) 波谱仪的采集

基本信息

批准号：
1725502
负责人：
Gary Lorigan
金额：
$ 83.61万
依托单位：
Miami University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-15 至 2021-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1725502&HistoricalAwards=false
关键词：
MRI Acquisition Pulsed Electron Paramagnetic

项目摘要

This award is supported by the Major Research Instrumentation Program (MRI) and the Chemistry Research Instrumentation Program. Professor Gary Lorigan from Miami University at Oxford (Ohio) and colleagues Michael Crowder, David Tierney, Carole Dabney-Smith and Richard Page are acquiring an X-/Q-band pulsed electron paramagnetic resonance (EPR) spectrometer. This instrument allows research in a variety of fields that study molecules with unpaired electrons such as biology and environmental studies. In general, an EPR spectrometer yields detailed information on the geometric and electronic structure of molecular and solid state materials. It may also be used to obtain information about the lifetimes of the unpaired electrons as they are short-lived, highly reactive species involved in many chemical transformations. Graduate and undergraduate students (including those from in an NSF Research Experiences for Undergraduates (REU) program) are trained in the researchers' laboratories to be competitive in careers in academia and industry. Students from the nearby Central State University (an Historically Black College or University (HBCU)) also have access to this instrumentation. This EPR spectrometer enhances research and education at all levels. It aids researchers in probing the structure of the KCNE1/Q1 channel complex; elucidating the binding mechanisms of different substrates and inhibitors for metallo-B-lactamases, and studying the electronic state of high-spin cobalt(II) magnetic materials and enzymes. The instrumentation is also used in determining the chloroplast membrane transport mechanisms and studying the proteins involved in muscle contraction and signal transduction. The spectrometer is employed in probing the protein-protein interactions of the CHIP/Hsp70 protein complex and investigating the structure/binding of homo/hetero-oligomeric proteins. Finally, the EPR spectrometer serves as a regional resource for other state institutions and nearby universities.

该奖项由主要研究仪器计划（MRI）和化学研究仪器计划支持。来自俄亥俄州牛津市迈阿密大学的Gary Lorigan教授及其同事Michael Crowder、David Tierney、Carole Dabney-Smith和Richard Page正在获得一台X / q波段脉冲电子顺磁共振（EPR）光谱仪。该仪器允许研究各种领域的分子与不成对的电子，如生物学和环境研究。一般来说，EPR光谱仪产生分子和固态材料的几何和电子结构的详细信息。它也可以用来获得关于未配对电子寿命的信息，因为它们是短暂的，在许多化学转化中涉及的高度反应的物种。研究生和本科生（包括那些来自NSF本科生研究经历（REU）计划的学生）在研究人员的实验室接受培训，以在学术界和工业界的职业生涯中具有竞争力。来自附近的中央州立大学（一所历史悠久的黑人学院或大学（HBCU））的学生也可以使用这种仪器。这种EPR光谱仪加强了各级的研究和教育。它有助于研究人员探测KCNE1/Q1通道复合物的结构；阐明不同底物和抑制剂对金属b -内酰胺酶的结合机制，研究高自旋钴（II）磁性材料和酶的电子态。该仪器还用于确定叶绿体膜运输机制和研究参与肌肉收缩和信号转导的蛋白质。该光谱仪用于探测CHIP/Hsp70蛋白复合物的蛋白-蛋白相互作用，并研究同源/异质寡聚蛋白的结构/结合。最后，EPR光谱仪作为其他国家机构和附近大学的区域资源。