MRI: Acquisition of a Variable Temperature Electron Paramagnetic Resonance (EPR) Spectrometer

该奖项由主要研究仪器，化学研究仪器计划和刺激竞争性研究的既定计划共同支持。路易斯维尔大学正在购买升级的X波段电子顺磁共振（EPR）光谱仪，以支持克雷格Grapperhaus教授沿着同事张翔的研究。该仪器有助于化学、物理化学、生物学和生物化学领域的研究。EPR光谱仪通过检测顺磁物质产生关于电子结构和分子间相互作用的详细信息。自由基是一种寿命短、反应性强的物质，其寿命和过渡金属离子可以在各种材料中被识别和量化。该仪器增强了路易斯维尔大学多个部门和两个主要本科院校（印第安纳州东南大学和贝拉明大学）各级学生的教育、研究和教学工作。EPR光谱仪的获奖旨在加强各级研究和教育，特别是在无碳燃料、电子和自旋电子材料、药理学应用、和糖尿病引起的细胞压力。具体而言，该仪器可用于广泛的项目，包括用于小分子活化的具有氧化还原活性配体的电催化剂和用于绿色有机合成的水溶性催化剂的研究。其他研究包括对细胞生命周期和基因启动子区转录调控元件所必需的高阶DNA的结构生物学研究。它还有助于对表现出催化活性的线粒体膜蛋白的基础研究和对活性氧诱导细胞过程的研究。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation, the Chemistry Research Instrumentation programs, and the Established Program to Stimulate Competitive Research. The University of Louisville is acquiring an upgraded X-band electron paramagnetic resonance (EPR) spectrometer to support the research of Professor Craig Grapperhaus along with colleague Xiang Zhang. This instrument facilitates research in the areas of chemistry, physical chemistry, biology, and biochemistry. An EPR spectrometer yields detailed information on electronic structure and intermolecular interactions by detecting paramagnetic species. Lifetimes of free radicals, which are short-lived, highly reactive species, and transition metal ions can be identified and quantified in a variety of materials. This instrument enhances the educational, research, and teaching efforts of students at all levels in multiple departments within the University of Louisville and at two primarily undergraduate institutions, Indiana University Southeast and Bellarmine University.The award of the EPR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as carbon-free fuels, electronic and spintronic materials, pharmacological applications, and cellular stress caused by diabetes. Specifically, the instrument enables a wide range of projects including electrocatalysts with redox active ligands for small molecule activation and studies of water-soluble catalysts for green organic synthesis. Other investigations include structural biology studies of higher order DNA that is essential for cell life cycles and transcription regulation elements in gene promotor regions. It also assists in the fundamental investigations of a mitochondrial membrane protein that exhibits catalytic activity and the study of reactive oxygen species inducing cell processes. Additionally, it enables the characterization of the magnetic properties of 2D magnetic materials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.