FASEB Summer Research Conference: Genetic Recombination and Genome Rearrangements to be held at Copper Mountain, Colorado from July 25-30, 1993

9302546罗斯坦这笔赠款提供了部分资金的FASEB Surnmer研究会议的遗传修饰和基因组重排，这是正在举行的7月25日至7月30日，1993年在铜山，CO。会议是在美国实验生物学学会联合会（FASEB）的赞助下。 本次会议的形式将与戈登研究会议所使用的相同。 将有9个主要会议，36名特邀发言人。 每届会议的主席将就历史背景和当前问题作介绍性发言，使所有与会者了解该届会议的主题。 在整个会议期间将举行海报会议。 将在会前或会上安排小组非正式研讨会。 主题将涵盖从哺乳动物细胞到细菌的广泛的生物体。 将介绍体内和体外方法。 该会议是美国唯一一个专门讨论基因重组和基因组重排的定期会议。 这次会议将讨论的主题是目前的基因治疗方法，导致癌症和其他疾病的基因组重排，连锁分析中的问题，同源重组的遗传学，同源重组的酶学（链转移酶、核酸酶和解离酶），重组中间体的物理结构，异源双链重组中间体中错配位点的修复，基因表达的位点特异性重组和调节，以及细菌和真核转座。 这次会议提供了一个重要的接口之间的科学家感兴趣的基本机制方面的重组和那些感兴趣的实际应用，如基因治疗，动物模型的疾病，和重塑基因组测试功能改变的基因调控序列。 ***

9302546 Rothstein This grant provides partial funding for a FASEB Surnmer Research Conference on Genetic Recombination and Genome Rearrangements, which is being held July 25 to July 30, 1993 in Copper Mountain, CO. The conference is under the auspices of the Federation of the American Societies of Experimental Biology (FASEB). The format of this meeting will be the same as that used by the Gordon Research Conferences. There will be nine major sessions with 36 invited speakers. The chairperson of each session will give an introductory talk on the historical background and the current problems to acquaint all participants with the topics in that session. Poster sessions will be held throughout the meeting. Informal workshops of small groups will be arranged before or at the meeting. Topics will cover a broad range of organisms from mammalian cells to bacteria. Both in vivo and in vitro approaches will be presented. This conference is the only regularly scheduled meeting in the United States that is devoted exclusively to genetic recombination and genome rearrangements. The topics to be covered at this meeting are current approaches to gene therapy, genome rearrangements that lead to cancer and other diseases, problems in linkage analysis, genetics of homologous recombination, enzymology of homologous recombination (strand transferases, nucleases, and resolvases), physical structure of recombination intermediates, repair of mismatch sites in heteroduplex recombination intermediates, site-specific recombination and regulation of gene expression, and bacterial and eukaryotic transposition. %%% This meeting provides a crucial interface between scientists interested in the basic mechanistic aspects of recombination and those interested in practical applications, such as gene therapy, creation of animal models of disease, and remodeling of genomes to test functional alterations of gene regulatory sequences. ***