FASEB Summer Research Conference: Genetic Recombination and Genome Rearrangements to be held at Copper Mountain, Colorado from July 25-30, 1993

9302546 Rothstein这笔赠款为1993年7月25日至7月30日在科罗拉多州铜山举行的关于遗传重组和基因组重排的FASE B Surnmer研究会议提供了部分资金。这次会议是由美国实验生物学学会联合会(FASE B)主办的。这次会议的形式将与戈登研究会议使用的相同。将有九个主要会议，36位受邀演讲者。每届会议主席将作介绍性演讲，介绍会议的历史背景和当前存在的问题，以使所有与会者了解会议的主题。招贴会将在整个会议期间举行。在会议之前或会议期间将安排小组的非正式讲习班。主题将涵盖从哺乳动物细胞到细菌的广泛有机体。将介绍体内和体外的方法。这次会议是美国唯一一次专门讨论基因重组和基因组重组的定期会议。本次会议将讨论的主题包括基因治疗的最新方法，导致癌症和其他疾病的基因组重排，连锁分析中的问题，同源重组的遗传学，同源重组的酶(链转移酶、核酸酶和分解酶)，重组中间体的物理结构，异源双链重组中间体错配位点的修复，基因表达的定点重组和调控，以及细菌和真核转座。这次会议为对重组的基本机制感兴趣的科学家和对实际应用感兴趣的科学家之间提供了一个重要的接口，如基因治疗、疾病动物模型的建立和基因组重塑以测试基因调控序列的功能变化。***

9302546 Rothstein This grant provides partial funding for a FASEB Surnmer Research Conference on Genetic Recombination and Genome Rearrangements, which is being held July 25 to July 30, 1993 in Copper Mountain, CO. The conference is under the auspices of the Federation of the American Societies of Experimental Biology (FASEB). The format of this meeting will be the same as that used by the Gordon Research Conferences. There will be nine major sessions with 36 invited speakers. The chairperson of each session will give an introductory talk on the historical background and the current problems to acquaint all participants with the topics in that session. Poster sessions will be held throughout the meeting. Informal workshops of small groups will be arranged before or at the meeting. Topics will cover a broad range of organisms from mammalian cells to bacteria. Both in vivo and in vitro approaches will be presented. This conference is the only regularly scheduled meeting in the United States that is devoted exclusively to genetic recombination and genome rearrangements. The topics to be covered at this meeting are current approaches to gene therapy, genome rearrangements that lead to cancer and other diseases, problems in linkage analysis, genetics of homologous recombination, enzymology of homologous recombination (strand transferases, nucleases, and resolvases), physical structure of recombination intermediates, repair of mismatch sites in heteroduplex recombination intermediates, site-specific recombination and regulation of gene expression, and bacterial and eukaryotic transposition. %%% This meeting provides a crucial interface between scientists interested in the basic mechanistic aspects of recombination and those interested in practical applications, such as gene therapy, creation of animal models of disease, and remodeling of genomes to test functional alterations of gene regulatory sequences. ***