Conference: FASEB Summer Research Conference on Dynamic DNA Structures in Biology, July 2018, St. Bonaventure University, Olean, NY

该奖项将支持研究生和博士后研究人员出席将于2018年7月8日至13日在纽约州奥利安市圣文德大学举行的FASEB生物学动态DNA结构会议。 这是一个不断发展的领域，继续汇集研究人员在核酸化学，生物化学，遗传学和基因组结构和功能的互补利益。 会议将包括该领域两位领导人的主旨演讲。正式会议将包括全体讲座，讲座和海报会议相结合，以鼓励分享最新的研究成果。 将为初级研究人员提供非正式的机会，在“会见演讲者”午餐会上向资深研究人员学习，并与学术界和工业界的高级研究人员进行职业讨论。 DNA分子是高度动态的，并且可以采用在基因和基因组的功能和调节中起重要作用的各种构象。 该领域的最新进展-包括基因编辑和染色质以及转录相关基因组不稳定性中的DNA损伤反应所发挥的作用-将在本次会议上重点介绍。 其他讨论的主题将是染色体断裂和基因组重排;结构诱导的基因组不稳定性;通过路障复制;转录诱导的突变;可扩展的DNA重复序列和人类疾病; DNA修复和重排，以及G-四链体。 会议将为初级研究人员提供一个很好的论坛，包括那些来自代表性不足的群体的研究人员，听取美国和国外的最新研究，与该领域的领导人会面和交谈，该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值进行评估来支持和更广泛的影响审查标准。

This award will support attendance by graduate students and postdoctoral researchers at the FASEB Conference on Dynamic DNA Structures in Biology to be held July 8-13, 2018 at St. Bonaventure University, Olean, NY. This is an evolving field that continues to bring together researchers with complementary interests in nucleic acid chemistry, biochemistry, genetics, and genome architecture and function. The meeting will include keynote lectures by two leaders in the field. Formal sessions will include a combination of plenary lectures, talks and poster sessions to encourage sharing of latest research results. Informal opportunities will be provided for junior researchers to learn from established investigators at a 'meet the speakers' lunch and a career discussion with senior researchers from both academia and industry. DNA molecules are highly dynamic and can adopt a variety of conformations that play important roles in the function and regulation of genes and genomes. Recent advances in the field--including gene editing and the role played by chromatin and the DNA damage response in transcription-associated genome instability--will be highlighted in this meeting. Other topics for discussion will be chromosome breaks and genomic rearrangements; structure-induced genome instability; replication through roadblocks; transcription-induced mutations; expandable DNA repeats and human disease; DNA repair and rearrangement, and G-quadruplexes. The meeting will bring provide an excellent forum for junior investigators, including those from underrepresented groups, to hear about latest research in the U.S. and abroad, to meet and talk with leaders in the field, and to have an opportunity to present and receive feedback on their own research.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.