FASEB Summer Research Conference: Phospholipid Metabolism: Disease, Signal Transd

描述（由申请人提供）：资金要求支持2012年（7月15日至20日，佛蒙特州学院），2014年和2016年的FASEB夏季研究会议的产品，题为：磷脂代谢：疾病，信号转导和膜生物物理学。该主题领域得到了NIH的大力支持，近500个活跃的项目由NIH研究所提供的资金支持，在过去的十年中，每年产生约5000篇同行评审的研究出版物。这是一个正在进行的会议，最初是在1988年作为“磷脂酶”会议提供的。该会议已从其最初的产品有很大的变化，现在包括与磷脂代谢，磷脂信号和膜生物物理学的主要学科。此外，随着该领域的研究越来越多地涉及多学科，会议对一般生物医学研究界的成员也越来越重要。在很大程度上，这是由代谢磷脂的酶的分子和药理学工具的可用性以及缺乏这些酶的敲除小鼠的可用性驱动的。这使得其他领域的研究人员能够研究磷脂在特定细胞功能以及生理和病理生理过程中的参与。会议强调了这些领域的进展，并重点关注脂质/蛋白质运输，核脂质信号传导和氧化磷脂，这些学科在过去并不是主要焦点。重点的转变不仅强调了组织者的研究兴趣，而且也是有意扩大会议的重点，以吸引可能不会参加会议的新研究人员。会议分为八个主题，其中包括30分钟的演讲，邀请演讲者是该领域的领导者，15分钟的演讲将从提交的摘要中选出。包括两个海报会议，以及由核心董事领导的脂质组学/脂质质谱的“最新技术水平”的非正式讨论。组织者将邀请年轻的调查人员介绍15分钟的演讲，并将利用这些时间段招募更多的女性演讲者和来自代表性不足的群体的演讲者。本提案中的资金将用于为这些个人提供旅费，并使他们能够携带实验室成员参加会议。 公共卫生相关性：资金要求支持2012年（7月15日至20日，佛蒙特州学院），2014年和2016年的FASEB夏季研究会议的产品，题为：磷脂代谢：疾病，信号转导和膜生物物理学。这是一个广泛的学科领域，包括基础科学和转化科学，强调动脉粥样硬化，糖尿病，炎症，癌症和其他疾病。这些资金将主要用于使年轻的研究人员能够参加会议，因为这些人的参与对于确保我们的学科继续发展以满足21世纪世纪的医疗保健需求至关重要。

DESCRIPTION (provided by applicant): Funds are requested to support for the 2012 (July 15-20, Vermont Academy), 2014, and 2016 offerings of the FASEB Summer Research Conference entitled: Phospholipid Metabolism: Disease, Signal Transduction, and Membrane Biophysics. The subject area receives considerable support from the NIH with nearly 500 active projects sustained by funds provided by NIH institutes and has generated ~5000 peer reviewed research publications each year in the past decade. This is an on-going conference that was first offered as a "phospholipases" meeting in 1988. The conference has changed substantially from its original offering and now encompasses most of the major disciplines related to phospholipid metabolism, phospholipid signaling, and membrane biophysics. Furthermore, the conference has become more relevant to members of the general biomedical research community, as research in the field had become increasingly multidisciplinary. In large part, this has been driven by the availability of molecular and pharmacological tools for enzymes that metabolize phospholipids and by availability of knockout mice lacking these enzymes. This has allowed researchers in other areas to investigate the involvement of phospholipids in specific cellular functions as well as physiological and pathophysiological processes. The meeting highlights advances in these areas and also focuses on lipid/ protein trafficking, nuclear lipid signaling, and oxidized phospholipids, disciplines that have not been major foci in the past. The shift in emphasis not only underscores the research interests of the organizers, but is also a deliberate attempt to broaden the focus of the meeting to engage new researchers who might not otherwise attend the conference. The meeting is organized into eight themes, which feature 30- minute talks by invited speakers who are leaders in the field and 15-minutes talks to be chosen from among submitted abstracts. Two poster sessions are included as well as an informal discussion of the "state of the art" of lipidomics/ lipid mass spectrometry led by Core Directors i the LIPID MAPS group. The Organizers will invite young investigators to present the 15-minute talks and will use these slots to recruit additional female speakers and speakers from underrepresented groups. Funds from this proposal will be used to provide travel awards for such individuals and also to enable them to bring members of their laboratories to the conference. PUBLIC HEALTH RELEVANCE: Funds are requested to support for the 2012 (July 15-20, Vermont Academy), 2014, and 2016 offerings of the FASEB Summer Research Conference entitled: Phospholipid Metabolism: Disease, Signal Transduction, and Membrane Biophysics. This is a broad subject area that encompasses both basic and translational science that underscores atherosclerosis, diabetes, inflammation, cancer, and other diseases. The funds will primarily be used to enable young investigators to attend the meeting as involvement of such individuals is essential to ensure that our discipline continues to evolve to meeting the health care needs of the 21st century.