FASEB Summer Research Conference: Phospholipid Metabolism: Disease, Signal Transd

申请者描述(由申请者提供)：请为2012年(7月15-20日，佛蒙特州科学院)、2014年和2016年举办的名为：磷脂代谢：疾病、信号转导和膜生物物理的FASEB夏季研究会议提供资金。该主题领域得到了NIH的大力支持，有近500个活跃的项目由NIH研究所提供的资金支持，在过去十年中，每年产生约5000份同行评议的研究出版物。这是一个正在进行的会议，于1988年首次提出作为“磷脂酶”会议。这次会议与最初的会议相比有了很大的变化，现在涵盖了与磷脂代谢、磷脂信号转导和膜生物物理学相关的大多数主要学科。此外，由于该领域的研究越来越多地成为多学科的研究，会议对一般生物医学研究界的成员变得更加相关。在很大程度上，这是由于代谢磷脂的酶的分子和药理学工具的可获得性，以及缺乏这些酶的基因敲除小鼠的可用性。这使得其他领域的研究人员能够研究磷脂在特定细胞功能以及生理和病理生理过程中的参与。会议强调了在这些领域取得的进展，还侧重于脂质/蛋白质贩运、核脂信号和氧化磷脂，这些学科在过去并不是主要焦点。这种重点的转移不仅突显了组织者的研究兴趣，也是一种刻意的尝试，目的是扩大会议的重点，以吸引本来可能不会参加会议的新研究人员。会议分为八个主题，其中包括由该领域领军人物的特邀演讲者发表30分钟的演讲，以及从提交的摘要中选择15分钟的演讲。其中包括两个海报会议，以及由脂类图谱小组的核心主任I领导的关于脂类组学/脂质谱“最新技术”的非正式讨论。组织者将邀请年轻调查人员介绍15分钟的演讲，并将利用这些空位招募更多女性演讲者和来自代表性不足群体的演讲者。这项提议的资金将用于为这些个人提供旅行奖励，并使他们能够将其实验室成员带到会议上。 公共卫生相关性：请拨资金支持2012年(7月15日至20日，佛蒙特州科学院)、2014年和2016年举办的题为：磷脂代谢：疾病、信号转导和膜生物物理学的FASEB夏季研究会议。这是一个广泛的学科领域，既包括基础科学，也包括强调动脉粥样硬化、糖尿病、炎症、癌症和其他疾病的翻译科学。这笔资金将主要用于使年轻研究人员能够出席会议，因为这些人的参与对于确保我们的学科继续发展以满足21世纪的卫生保健需求至关重要。

DESCRIPTION (provided by applicant): Funds are requested to support for the 2012 (July 15-20, Vermont Academy), 2014, and 2016 offerings of the FASEB Summer Research Conference entitled: Phospholipid Metabolism: Disease, Signal Transduction, and Membrane Biophysics. The subject area receives considerable support from the NIH with nearly 500 active projects sustained by funds provided by NIH institutes and has generated ~5000 peer reviewed research publications each year in the past decade. This is an on-going conference that was first offered as a "phospholipases" meeting in 1988. The conference has changed substantially from its original offering and now encompasses most of the major disciplines related to phospholipid metabolism, phospholipid signaling, and membrane biophysics. Furthermore, the conference has become more relevant to members of the general biomedical research community, as research in the field had become increasingly multidisciplinary. In large part, this has been driven by the availability of molecular and pharmacological tools for enzymes that metabolize phospholipids and by availability of knockout mice lacking these enzymes. This has allowed researchers in other areas to investigate the involvement of phospholipids in specific cellular functions as well as physiological and pathophysiological processes. The meeting highlights advances in these areas and also focuses on lipid/ protein trafficking, nuclear lipid signaling, and oxidized phospholipids, disciplines that have not been major foci in the past. The shift in emphasis not only underscores the research interests of the organizers, but is also a deliberate attempt to broaden the focus of the meeting to engage new researchers who might not otherwise attend the conference. The meeting is organized into eight themes, which feature 30- minute talks by invited speakers who are leaders in the field and 15-minutes talks to be chosen from among submitted abstracts. Two poster sessions are included as well as an informal discussion of the "state of the art" of lipidomics/ lipid mass spectrometry led by Core Directors i the LIPID MAPS group. The Organizers will invite young investigators to present the 15-minute talks and will use these slots to recruit additional female speakers and speakers from underrepresented groups. Funds from this proposal will be used to provide travel awards for such individuals and also to enable them to bring members of their laboratories to the conference. PUBLIC HEALTH RELEVANCE: Funds are requested to support for the 2012 (July 15-20, Vermont Academy), 2014, and 2016 offerings of the FASEB Summer Research Conference entitled: Phospholipid Metabolism: Disease, Signal Transduction, and Membrane Biophysics. This is a broad subject area that encompasses both basic and translational science that underscores atherosclerosis, diabetes, inflammation, cancer, and other diseases. The funds will primarily be used to enable young investigators to attend the meeting as involvement of such individuals is essential to ensure that our discipline continues to evolve to meeting the health care needs of the 21st century.