Adsorption Dynamics of Mixed Surfactants and Proteins at Air/Water Interfaces: Applications to Foams and Lung Surfactants

小行星9304328 该项目研究了表面活性剂、脂质和蛋白质在空气/水界面的动态表面张力和吸附行为。 动态吸附在基于泡沫的从稀溶液中分离有毒或有用的化学品中是重要的。 它在滑行流、农药喷洒效率、疏水分子的下游生物加工以及用于治疗早产儿呼吸窘迫综合征的肺表面活性剂制剂中也很重要。 目的是研究不同类型的表面活性剂和蛋白质的分子相互作用如何影响竞争吸附行为。 在恒定面积或脉动面积条件下测量动态表面张力。 表面吸附密度估计从表面电位测量，从使用放射性示踪剂，并从采样的表面单分子层通过使用朗缪尔-布洛杰特沉积法。 此外，正在建造一个探测动态浓度分布的装置。 结果与运输-吸附描述模型相关，并用于解释辛醇，十二烷基硫酸钠，牛血清白蛋白，溶菌酶和其他分子的泡沫浓度和泡沫分馏实验。 最后，研究了十六醇、二棕榈酰磷脂酰胆碱、泰洛沙泊和SP-A、SP-B和SP-C（肺特异性蛋白质）在肺表面活性剂制剂中的重要性。

9304328 Frances The project examines the dynamic surface tension and adsorption behavior of surfactants, lipids, and proteins at the air/water interface. Dynamic adsorption is important in foam-based separations of toxic or useful chemicals from dilute solutions. It is also important in coasting flows, pesticide spray efficiency, downstream bioprocessing of hydrophobic molecules, and in lung surfactant formulations for treating the respiratory distress syndrome of premature infants. The objectives are to study how different kinds of molecular interactions of various surfactants and proteins affect the competitive adsorption behavior. Dynamic surface tensions area measured either at constant area or at pulsating area conditions. Surface adsorption densities are estimated from surface electrical potential measurements, from using radiotracers, and from sampling the surface monolayers by the use of Langmuir-Blodgett deposition method. Moreover, an apparatus is being built for probing dynamic concentration profiles. The results are correlated with transport- adsorption description models and are used in interpreting foam - concentration and foam fractionation experiments of octanol, sodium dodecylsulfate, bovine serum albumin, lysozyme, and other molecules. Finally, hexadecanol, dipalmitoylphosphatidylcholine, tyloxapol, and SP-A, SP-B, and SP-C (lung specific proteins) are studied for their importance in lung surfactant formulations.