Adsorption Dynamics of Mixed Surfactants and Proteins at Air/Water Interfaces: Applications to Foams and Lung Surfactants

混合表面活性剂和蛋白质在空气/水界面的吸附动力学：在泡沫和肺表面活性剂中的应用

• 批准号: 9304328
• 负责人: Elias Franses
• 金额: $ 24万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1997-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9304328&HistoricalAwards=false
• 关键词: Adsorption; Dynamics; Mixed; Surfactants; Proteins

9304328 Frances The project examines the dynamic surface tension and adsorption behavior of surfactants, lipids, and proteins at the air/water interface. Dynamic adsorption is important in foam-based separations of toxic or useful chemicals from dilute solutions. It is also important in coasting flows, pesticide spray efficiency, downstream bioprocessing of hydrophobic molecules, and in lung surfactant formulations for treating the respiratory distress syndrome of premature infants. The objectives are to study how different kinds of molecular interactions of various surfactants and proteins affect the competitive adsorption behavior. Dynamic surface tensions area measured either at constant area or at pulsating area conditions. Surface adsorption densities are estimated from surface electrical potential measurements, from using radiotracers, and from sampling the surface monolayers by the use of Langmuir-Blodgett deposition method. Moreover, an apparatus is being built for probing dynamic concentration profiles. The results are correlated with transport- adsorption description models and are used in interpreting foam - concentration and foam fractionation experiments of octanol, sodium dodecylsulfate, bovine serum albumin, lysozyme, and other molecules. Finally, hexadecanol, dipalmitoylphosphatidylcholine, tyloxapol, and SP-A, SP-B, and SP-C (lung specific proteins) are studied for their importance in lung surfactant formulations.

该项目研究了空气/水界面上表面活性剂、脂质和蛋白质的动态表面张力和吸附行为。动态吸附在以泡沫为基础的从稀溶液中分离有毒或有用化学品的过程中是很重要的。它在滑行流、农药喷洒效率、疏水分子的下游生物处理以及用于治疗早产儿呼吸窘迫综合征的肺表面活性物质配方中也很重要。目的是研究不同种类的表面活性剂和蛋白质的分子相互作用如何影响竞争吸附行为。在恒定面积或脉动面积条件下测量的动态表面张力面积。表面吸附密度通过表面电势测量、使用放射性示踪剂和使用Langmuir-Blodgett沉积法对表面单层取样来估计。此外，正在建造一种仪器来探测动态浓度剖面。结果与运输-吸附描述模型相关联，并用于解释辛醇、十二烷基硫酸钠、牛血清白蛋白、溶菌酶和其他分子的泡沫浓度和泡沫分馏实验。最后，研究了十六醇、双棕榈酰磷脂酰胆碱、泰洛沙酚和SP-A、SP-B和SP-C（肺特异性蛋白）在肺表面活性剂配方中的重要性。