U.S.-Korea Cooperative Research on Development of Empirical Potential Functions for Protein Folding

美韩合作开发蛋白质折叠经验势函数

• 批准号: 9306345
• 负责人: Harold Scheraga
• 金额: $ 3.84万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-01 至 1998-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9306345&HistoricalAwards=false
• 关键词: U.S.; Korea; Cooperative; Research; Development

9306345 Scheraga This award provides funds to permit Dr. Harold A. Scheraga, Department of Chemistry, Cornell University, to pursue with Professor Mu Shik Jhon, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), and Dr. Kyoung Tai No, Department of Chemistry, Soong-Sil University, Korea, for 36 months, a program of cooperative research on the development of empirical potential functions for protein folding. This theoretical research is designed to elucidate the energies and mechanism of the folding of a polypeptide chain into the native conformation of a protein. While current potential functions, developed by the collaborators, are sufficiently accurate for several applications, the collaborators will develop new and better potential functions which will have greater applicability. This research is important for developing a better understanding of the structure and properties of proteins. The collaborators are highly respected researchers in the field of the proposal. This project is relevant to the objectives of the U.S.-Korea Cooperative Science Program which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit. Korean participation in the project is supported by the Korea Science and Engineering Foundation (KOSEF). This project adds an international cooperative dimension to the PI's research under NSF Grant No. DMB-9015815. ***

9306345 Scheraga该奖项提供资金，允许康奈尔大学化学系Harold A.Scheraga博士与韩国高等科学技术研究院(KAIST)化学系Mu Shik Jhon教授和韩国宋西大学化学系KYoung Tai No博士进行为期36个月的合作研究计划，以开发蛋白质折叠的经验潜在函数。这项理论研究旨在阐明多肽链折叠成蛋白质天然构象的能量和机制。虽然目前由合作者开发的潜在功能对于几个应用来说足够准确，但合作者将开发新的、更好的潜在功能，这些功能将具有更大的适用性。这项研究对于更好地了解蛋白质的结构和性质具有重要意义。合作者是该提案领域备受尊敬的研究人员。该项目与美韩合作科学计划的目标相关，该计划旨在通过交流科学信息、想法、技能和技术以及通过在互利问题上的合作来提高美国和韩国科学家和工程师之间的合作水平。韩国参与该项目得到了韩国科学与工程基金会(KOSEF)的支持。该项目增加了国际合作的层面，国际和平研究所的研究在美国国家科学基金会补助金编号。Dmb-9015815。***