U.S.-Hungary Biophysics Research on Low Energy Conformation of Polypeptides

美匈生物物理学研究多肽低能构象

• 批准号: 8822275
• 负责人: Harold Scheraga
• 金额: $ 2.09万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-01 至 1992-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8822275&HistoricalAwards=false
• 关键词: U.S.; Hungary; Biophysics; Research; Low

The primary objective of this U. S.- Hungary cooperative research project between Dr. Harold Scheraga of Cornell University and Dr. Istvan Simon of the Institute of Enzymology, Hungarian Academy of Sciences, is to pursue theoretical studies of protein folding. A promising statistical approach, characterized as "build-up," will be employed to combine conformational energy calculations on oligopeptides with statistical analyses of amino acid sequences and of three dimensional protein structures. Results may yield a rational, effective approach for determining the conformation of low-energy peptides. This project in biophysics fulfills the program objective of advancing scientific knowledge by enabling experts in the United States and Eastern Europe to combine complementary talents and pool research resources in areas of strong mutual interest and competence.

康奈尔大学 Harold Scheraga 博士和匈牙利科学院酶学研究所 Istvan Simon 博士之间的这项美国-匈牙利合作研究项目的主要目标是进行蛋白质折叠的理论研究。 一种有前途的统计方法，其特征为“构建”，将用于将寡肽的构象能量计算与氨基酸序列和三维蛋白质结构的统计分析结合起来。 结果可能会产生一种合理、有效的方法来确定低能肽的构象。 该生物物理学项目通过使美国和东欧的专家能够在共同感兴趣和能力强的领域结合互补人才并汇集研究资源，实现了推进科学知识的计划目标。