U.S.-Hungary Biophysics Research on Low Energy Conformation of Polypeptides

康奈尔大学的Harold Scheraga博士和匈牙利科学院酶研究所的Istvan Simon博士的这项美国-匈牙利合作研究项目的主要目标是继续蛋白质折叠的理论研究。一种很有前途的统计学方法，其特征是“建立”，将被用来将低聚肽的构象能量计算与氨基酸序列和三维蛋白质结构的统计分析结合起来。结果为确定低能多肽的构象提供了一种合理、有效的方法。这个生物物理学项目通过使美国和东欧的专家能够将互补的人才结合在一起，并在相互感兴趣和能力很强的领域汇集研究资源，实现了促进科学知识的计划目标。

The primary objective of this U. S.- Hungary cooperative research project between Dr. Harold Scheraga of Cornell University and Dr. Istvan Simon of the Institute of Enzymology, Hungarian Academy of Sciences, is to pursue theoretical studies of protein folding. A promising statistical approach, characterized as "build-up," will be employed to combine conformational energy calculations on oligopeptides with statistical analyses of amino acid sequences and of three dimensional protein structures. Results may yield a rational, effective approach for determining the conformation of low-energy peptides. This project in biophysics fulfills the program objective of advancing scientific knowledge by enabling experts in the United States and Eastern Europe to combine complementary talents and pool research resources in areas of strong mutual interest and competence.