Synthesis of Carbocyclic and Heterocyclic Natural Products

碳环和杂环天然产物的合成

• 批准号: 9316939
• 负责人: James White
• 金额: $ 41.5万
• 依托单位: Oregon State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-12-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9316939&HistoricalAwards=false
• 关键词: Synthesis; Carbocyclic; Heterocyclic; Natural; Products

9316939 White The focus of this research is the discovery of new synthetic methods and their application to the synthesis of certain carbocyclic and heterocyclic compounds of natural origin. Five natural products are identified for the purpose of defining the specific goals of the project. They fall into two groups, one consisting of a set for which bond reorganization involving a cyclobutane is the focal step, and another in which elaboration of a heterocyclic subunit plays a pivotal role. The first group contains rubratoxin B, verrucarol, and huperzine A. The second group contains the alkaloids cylindrospermopsin and koumine. The major emphasis in all of the syntheses is the ability to complete efficient routes to structures containing a high degree of complexity. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. James D. White of the Department of Chemistry at Oregon State University. Professor White will focus his work on the discovery of new synthetic methods and their application to the synthesis of certain carbocyclic and heterocyclic compounds of natural origins. The molecular architecture of the designated target compounds presents a significant challenge to contemporary methods of synthesis which will be addressed by exploring unconventional and, in several instances, unprecedented approaches to their construction. ***

9316939白色 这项研究的重点是发现新的合成 方法及其在合成某些 天然来源的碳环和杂环化合物。五 天然产品的目的是确定 项目的具体目标。他们分为两组，一组 包括一套债券重组， 环丁烷是重点步骤，另一个是精心制作 杂环亚基的结构起着关键的作用。第一组 含有红曲霉毒素B、疣卡酚和石杉碱甲。第二 组含有生物碱柱孢菌素和钩吻素。 在所有的综合的主要重点是能力， 完全有效的路线，以结构包含高 复杂程度。 有了这个奖项，合成有机计划正在支持 James D.的研究。司法部的白色 化学在俄勒冈州州立大学。白色教授将 他的工作重点是发现新的合成方法， 它们在合成某些碳环和 天然来源的杂环化合物分子 指定目标化合物的结构呈现出 对当代合成方法重大挑战 这将通过探索非传统的， 在一些情况下，前所未有的方法， 建设 ***