Synthesis of Carbocyclic and Heterocyclic Natural Products

碳环和杂环天然产物的合成

• 批准号: 9711187
• 负责人: James White
• 金额: $ 42.9万
• 依托单位: Oregon State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9711187&HistoricalAwards=false
• 关键词: Synthesis; Carbocyclic; Heterocyclic; Natural; Products

The foci of this research are threefold. First, the intramolecular addition of nitrile oxides to alkenes will be used as an entry to the synthesis of phomactin A and cornutin A. Second, epoxides will be transformed into cyclopropanes and the methodology applied to the preparation of the unusual Streptomyces metabolites FR-900,848 and U-106,305. Third, synthetic routes to compounds of the nonadride family of natural products will be explored. With this renewal award, the Synthetic Organic Program is supporting the research of Dr. James D. White of the Department of Chemistry at Oregon State University. Professor White will focus his work on developing total synthetic approaches to several natural products that possess interesting biochemical properties.

这项研究的重点有三个方面。首先，丁腈氧化物与烯烃的分子内加成反应将被用作合成鱼腥草素A和角质素A的入口。其次，环氧化物将转化为环丙烷，并应用于制备特殊的链霉菌代谢物FR-900,848和U-106,305的方法。第三，将探索合成二十九碳化合物系列天然产物的路线。有了这一续期奖，合成有机计划将支持俄勒冈州立大学化学系的詹姆斯·D·怀特博士的研究。怀特教授将把工作重点放在开发几种具有有趣生化特性的天然产品的全合成方法上。