Molecular Systematics of the Primates

本研究获得的分子DNA序列数据将对灵长类动物分类学和分子进化的理解做出重要贡献。首先，本研究将评估关于两个主要灵长类群体——新世界猴和旧世界猴之间关系的几种不同假设。结合来自几个非连锁基因位点的分子数据，正如本研究将要做的那样，将增加对任何新兴分子共识系统发育的信心-在这个水平上有许多未解决的问题。其次，这项研究将有助于在哺乳动物辐射过程中对线粒体基因进行广泛的分子进化调查。这将意味着我们可以在很长一段时间内分析不同生物中线粒体基因的分子进化，揭示可能无法观察到的模式。第三，本研究将详细研究分子适应的一个例子，特别是高等灵长类动物中COII基因变化的增长率。第四，这项研究将有助于检验确定分子进化速率的三种一般理论——a)“男性驱动的分子进化”，b)突变率的“核苷酸生成假说”，以及c)“代谢率假说”。该项目还为分子生物学和人类学方面的年轻专业人员提供了强有力的培训。* * * P人类学\ jfried \ \ 9319021。腹肌 \d f " $ 8 = Z \!!!!!D \ \ (Times New Roman Symbol & Arial " h 4 % 4 % yi = Jonathan Friedlaender

ABSTRACT P.I. Maryellen Ruvolo SBR-9319021 The molecular DNA sequence data obtained in this study will make several important contributions to primate systematics and to our understanding of molecular evolution. First, this study will evaluate several alternative hypotheses about the relationships of two major primate groups, the New World and Old World monkeys. Combining molecular data from several unlinked gene loci, as this study will do, will increase confidence in any emerging molecular consensus phylogeny - there are a number of unresolved issues at this level. Second, this study will contribute to an extensive molecular evolutionary survey of a mitochondrial gene throughout the mammalian radiation. This will mean that we can analyze the molecular evolution of a mitochondrial gene over a grat time depth in diverse organisms, uncovering patterns which might not otherwise be ovservable. Third, this research will study an example of molecular adaptation in detail - particularly the rate of increase in the COII gene change in higher primates. Fourth, the research will contribute to testing three general theories determining rates of molecular evolution - a) "male driven molecular evolution," b) the "nucleotide generation hypothesis" of mutation rates, and c) the "metabolic rate hypothesis." The project also has a strong training component for young professionals in molecular biology and anthropology. *** P\anthro\jfried\9319021.abs \ d f " $ 8 = Z \ ! ! ! ! ! D \ \ ( Times New Roman Symbol & Arial " h 4 % 4 % ı = Jonathan Friedlaender Jonathan Friedlaender