Molecular Systematics of the Primates

摘要 P.I. Maryellen Ruvolo SBR-9319021 本研究获得的分子DNA序列数据将对灵长类系统学和我们对分子进化的理解做出几个重要贡献。 首先，本研究将评估关于两个主要灵长类动物群体（新世界猴和旧世界猴）关系的几个替代假设。 正如这项研究所做的那样，结合来自几个非连锁基因位点的分子数据，将增加对任何新兴的分子共识遗传学的信心-在这个水平上还有许多未解决的问题。 其次，这项研究将有助于在整个哺乳动物辐射线粒体基因的广泛的分子进化调查。 这将意味着我们可以分析不同生物体中线粒体基因的分子进化，揭示可能无法观察到的模式。 第三，这项研究将详细研究分子适应的一个例子-特别是高等灵长类动物中COII基因变化的增加率。 第四，这项研究将有助于检验决定分子进化速率的三个一般理论-- a）“男性驱动的分子进化”，B）突变速率的“核苷酸生成假说”，以及c）“代谢速率假说”。" 该项目还为分子生物学和人类学的年轻专业人员提供了强有力的培训。 [*] P\anthro\jfried\9319021.abs \ D F " $ 8 = Z \ ! ! ! ! ! D \ \ ( Times New Roman 符号Arial " H 4% 4% ı = 乔纳森·弗里德兰德

ABSTRACT P.I. Maryellen Ruvolo SBR-9319021 The molecular DNA sequence data obtained in this study will make several important contributions to primate systematics and to our understanding of molecular evolution. First, this study will evaluate several alternative hypotheses about the relationships of two major primate groups, the New World and Old World monkeys. Combining molecular data from several unlinked gene loci, as this study will do, will increase confidence in any emerging molecular consensus phylogeny - there are a number of unresolved issues at this level. Second, this study will contribute to an extensive molecular evolutionary survey of a mitochondrial gene throughout the mammalian radiation. This will mean that we can analyze the molecular evolution of a mitochondrial gene over a grat time depth in diverse organisms, uncovering patterns which might not otherwise be ovservable. Third, this research will study an example of molecular adaptation in detail - particularly the rate of increase in the COII gene change in higher primates. Fourth, the research will contribute to testing three general theories determining rates of molecular evolution - a) "male driven molecular evolution," b) the "nucleotide generation hypothesis" of mutation rates, and c) the "metabolic rate hypothesis." The project also has a strong training component for young professionals in molecular biology and anthropology. *** P\anthro\jfried\9319021.abs \ d f " $ 8 = Z \ ! ! ! ! ! D \ \ ( Times New Roman Symbol & Arial " h 4 % 4 % ı = Jonathan Friedlaender Jonathan Friedlaender