Highly Enantioselective Dirhodium(II) Catalysts

9319962具有桥连手性的Doyle Dirhodium（II）催化剂 酰胺配体将被开发用于高度 对映选择性金属卡宾和其它化学品 转变发展高效、高效、 用于金属卡宾反应的对映选择性催化剂 重氮酮，用于氮丙啶化，用于刘易斯酸促进的 反应，并进行硼氢化。新 聚合物负载的手性铑（II）催化剂将是 准备好了，注意力将集中在增加 催化剂周转次数超过1000次。的主要目标 本项目将合成手性二铑（II） 具有高转化数的催化剂 对映体纯的单一产物。 %有机动力学计划的这一赠款支持 迈克尔·P·道尔教授在Trinity学院的继续工作 大学大多数生物学上重要的分子 手性或手性区域。换句话说， 区域是作为一个人的右手与一个人的左手相关的。 这种手性对于生物活性是必不可少的。在这 研究，手性催化剂，纳入铑将是 制备并用于进行反应，其中产物 的反应是手性的。这些反应包括 将CH 2单元加成到碳-碳双键上， 得到一种手性化合物， 循环数组 ***

9319962 Doyle Dirhodium(II) catalysts that possess bridging chiral carboxamide ligands will be developed for highly enantioselective metal carbene and other chemical transformations. The development of effective, highly enantioselective catalysts for metal carbene reactions of diazoketones, for aziridination, for Lewis acid-promoted reactions, and for hydroboration will be undertaken. New polymer-supported chiral dirhodium(II) catalysts will be prepared, and attention will be directed to increasing catalyst turnover numbers beyond 1000. The major goal of this project will be the synthesis of chiral dirhodium(II) catalysts that have high turnover numbers for the formation of single products that are enantiomerically pure. %%% This grant from the Organic Dynamics Program supports the continuing work of Professor Michael P. Doyle at Trinity University. Most biologically important molecules possess regions of chirality or handedness. In other words, these regions are related as ones right hand to ones left hand. This chirality is essential for biological activity. In this research, chiral catalysts which incorporate rhodium will be prepared and used to carry out reactions where the product of the reaction is chiral. These reactions include the addition of a CH2 unit to a carbon-carbon double bond to give a chiral compound which contains three carbon in a cyclic array. ***