Acquisition of a High Resolution Mass Spectrometer

购置高分辨率质谱仪

• 批准号: 0946988
• 负责人: Michael Doyle
• 金额: $ 33.69万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0946988&HistoricalAwards=false
• 关键词: Acquisition; Resolution; Mass; Spectrometer

Professors Michael P. Doyle, Jeffrey T. Davis, Daniel E. Falvey, Lyle D. Issacs and Herman O. Sintim of the University of Maryland have submitted a proposal in response to the CRIF: MU solicitation to acquire a high resolution double sector mass spectrometer. The research projects it will support are related to a variety of studies including: (i) synthesis and application of unnatural amino acids; (ii) characterization of small molecule intermediates used in supramolecular chemistry, molecular recognition, and the assembly of receptors for transmembrane ion-transport; (iii) development of highly selective and efficient catalytic processes for the synthesis of biologically relevant compounds; (iv) the study of photo induced electron transfer reactions and the generation of novel high spin organic species; (v) development of small molecule probes for electron and electrophile migration along strands of DNA; and, (vi) total synthesis of antibiotics of the family of Platensimycin. Mass spectrometry (MS) is used to identify the chemical composition of a sample and determine its purity. A high resolution mass spectrometer has the capability of performing accurate elemental composition analysis of compounds. This makes it a powerful tool for identification of known and unknown or new compounds. This acquisition will benefit undergraduate and graduate students in their research and in a new experimental course to be developed. Students and faculty at Howard University Virginia State University and Catholic University will also use it to analyze samples.

马里兰大学的Michael P. Doyle、Jeffrey T. Davis、Daniel E. Falvey、Lyle D. Issacs和Herman O. Sintim教授提交了一份提案，以响应CRIF: MU的招标，获得一台高分辨率双扇区质谱仪。它将支持的研究项目涉及各种研究，包括：(i)非天然氨基酸的合成和应用；（ii）表征用于超分子化学、分子识别和跨膜离子运输受体组装的小分子中间体；（iii）开发高选择性和高效的催化工艺，用于合成与生物有关的化合物；(4)光诱导电子转移反应的研究和新型高自旋有机物质的生成；(v)开发用于电子和亲电试剂沿DNA链迁移的小分子探针；（六）铂霉素科抗生素的全合成。质谱法（MS）用于鉴定样品的化学成分并确定其纯度。高分辨率质谱仪具有对化合物进行精确元素组成分析的能力。这使它成为鉴定已知和未知或新化合物的有力工具。这项收购将有利于本科生和研究生的研究和一个新的实验课程的发展。霍华德大学、弗吉尼亚州立大学和天主教大学的学生和教师也将使用它来分析样本。