Acquisition of a Nuclear Magnetic Resonance Spectrometer

购置核磁共振波谱仪

• 批准号: 1625963
• 负责人: Michael Doyle
• 金额: $ 52.73万
• 依托单位: University of Texas at San Antonio
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1625963&HistoricalAwards=false
• 关键词: Acquisition; Nuclear; Magnetic; Resonance; Spectrometer

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Michael Doyle from the University of Texas San Antonio (UTSA) has acquired a 500 MHz NMR spectrometer equipped with a broadband probe. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically-relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists to determine the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the changing interactions between molecules in solution or in the solid state. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is located a general user facility managed by highly qualified scientists and is an integral part of research, research training and teaching in the Departments of Chemistry and Biochemistry at this institution. The spectrometer helps in the overall university mission by providing students in South Texas with NMR knowledge and enabling their success in the chemical/engineering workforce. Several other regional universities: Texas Lutheran University, St. Mary's University, TAMU Kingsville and the University of Incarnate Word also use the instrument through collaborations.The award is aimed at enhancing research and education at all levels, especially in: (a) synthesizing heterocyclic compounds enantioselectively; (b) exploring new catalytic approaches to the highly stereoselective syntheses of structurally complex organic compounds; (c) characterizing the dynamic conformational changes of proteins; (d) exploring bioinorganic chemical catalysis, and (e) synthesizing and biophysically understanding biomaterials.

在主要研究仪器项目（MRI）和化学研究仪器项目（CRIF）的支持下，德克萨斯大学圣安东尼奥分校（UTSA）的Michael Doyle教授获得了一台配备宽带探针的500 MHz核磁共振光谱仪。该光谱仪允许在各种领域的研究，如那些加速具有重要经济意义的化学反应，以及对生物相关物种的研究。总的来说，核磁共振（NMR）光谱是化学家确定分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的变化。这些核磁共振研究的结果在合成有机/无机化学、材料化学和生物化学等领域具有重要影响。该仪器位于由高素质科学家管理的一般用户设施中，是该机构化学系和生物化学系研究，研究培训和教学的组成部分。该光谱仪通过为南德克萨斯州的学生提供核磁共振知识并使他们在化学/工程劳动力中取得成功，从而帮助整个大学的使命。其他几所地区性大学：德克萨斯路德大学、圣玛丽大学、TAMU Kingsville和道成肉身大学也通过合作使用该仪器。该奖项旨在加强各级的研究和教育，特别是在：(a)对映选择性地合成杂环化合物；(b)探索高立体选择性合成结构复杂有机化合物的新催化方法；(c)描述蛋白质的动态构象变化；(d)探索生物无机化学催化，(e)合成和生物物理理解生物材料。