Charting the human brain connectome over the lifespan

绘制人类大脑连接组在整个生命周期的图表

• 批准号: FT220100091
• 负责人: Prof Andrew Zalesky
• 金额: $ 72.1万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-06-30 至 2027-06-29
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT220100091
• 关键词: Charting; human; brain; connectome; over

This project aims to develop neuroimaging reference charts for the human connectome and track the vast individual variability in brain connectivity across the life course. Connectomes will be mapped using tractography and diffusion magnetic resonance imaging data for 40,000 individuals, establishing the largest connectome biobank to date. Expected outcomes include an innovative lifespan brain charting platform, new paradigms to model individual brain variability and knowledge of how cognition, lifestyle and environment shape brain ageing. Brain charting will usher in a new era of precision connectomics, paving the way towards neuroscience-based personalisation of pathways in education, employment and wellbeing.

该项目旨在为人类连接体开发神经成像参考图表，并跟踪整个生命过程中大脑连接的巨大个体差异。将使用纤维束成像和扩散磁共振成像数据绘制40，000人的连接体，建立迄今为止最大的连接体生物库。预期成果包括一个创新的生命周期大脑制图平台，模拟个体大脑变异性的新范式，以及认知、生活方式和环境如何塑造大脑衰老的知识。大脑制图将迎来一个精确连接组学的新时代，为教育、就业和福祉方面基于神经科学的个性化途径铺平道路。