Surface Modification of Polymeric Membranes for Low Protein Fouling

聚合物膜表面改性以降低蛋白质污染

• 批准号: 9400610
• 负责人: Georges Belfort
• 金额: $ 27.53万
• 依托单位: Rensselaer Polytechnic Institute
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-02-01 至 2000-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9400610&HistoricalAwards=false
• 关键词: Surface; Modification; Polymeric; Membranes; Low

9400610 Rensselaer Polytech Inst. Georges Belfort The surface of a commercially available polymeric membrane material, poly(arylsulfone), will be modified in order to reduce fouling when exposed to proteins during filtration. Two different approaches of surface modification will be investigated. One approach will use a novel photochemical method of grafting different monomers on the surface of poly(arylsulfone) non-porous films and membranes. The other method will involve low temperature plasma treatment with a series of monomers under varying conditions. The modified surfaces will be characterized using appropriate analytical techniques. The filtration performance of the modified membranes which show most potential will be evaluated. The correlation of surface properties to membrane filtration performance may lead to the design of membranes with low fouling due to protein adsorption. Effective reduction of membrane fouling is necessary for the wide scale application of membrane separations in various area including biotechnology, water treatment and hence civil infrastructure, and manufacturing.

9400610伦斯勒理工学院乔治·贝尔福特将对商用聚合物膜材料--聚芳基砜的表面进行改性，以减少过滤过程中暴露在蛋白质中的污染。我们将研究两种不同的表面改性方法。一种方法是使用一种新颖的光化学方法，将不同的单体接枝到聚芳基砜无孔薄膜和膜的表面。另一种方法是在不同条件下用一系列单体进行低温等离子体处理。将使用适当的分析技术对修改后的表面进行表征。将对最具潜力的改性膜的过滤性能进行评估。膜的表面性质与膜过滤性能的相关性可能导致设计出低污染的蛋白质吸附膜。有效地减少膜污染对于膜分离在生物技术、水处理以及民用基础设施和制造业等领域的广泛应用是必要的。