EAGER: Enhanced Performance Membranes by Scalable High Throughput Modification
EAGER:通过可扩展的高通量改性增强膜性能
基本信息
- 批准号:1122780
- 负责人:
- 金额:$ 10万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-05-15 至 2012-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This EAGER Grant application involves a radically different approach to membrane synthesis and testing, applies new expertise (high throughput platform (HTP) modification method with photo-induced graft polymerization (PGP) (HTP-PGP) method with surface agitation and measurement of protein sieving), and engages novel interdisciplinary perspectives (combines knowledge of polymer chemistry and fluid mechanics). Few polymers have been used for membrane filtration production over the past 35 years, because of effort, expense and time. A novel, fast, efficient and reproducible high throughput platform (HTP) modification method with photo-induced graft polymerization (PGP) (HTP-PGP method) that allowed synthesis and selection of the most protein fouling-resistant polymer from 66 functionalized surfaces for membrane separations has been developed. However, this new HTP-PGP method is not easily scalable and needs to include mixing and protein sieving to be really useful and predictable with high confidence. The fast, efficient and reproducible HTP-PGP method is a major contribution to the high throughput synthesis, screening and selection for material science and membrane technology. HTP-PGP selected previously reported protein-resistant surface chemistries, discovered several new monomers and gave reproducible results. However, for the HTP-PGP to be truly useful for fundamental studies and scalable for industrial applications, it should also include cross-flow with time-dependent tracking of permeation volume and solute (sieving) flux. In this research, HTP-PGP will be transformed so that it can evaluate and select the best polymers from many 100s of functionalized surfaces under scalable conditions; and analyze the mechanism of grafting to gain understanding for future design of surfaces for membrane separations. With previous results over the past 17 years with membrane surface modification and the HTP-PGP method as a springboard, the following two specific aims for the research with the 96 filter-well format are proposed: 1. To implement and model crossflow (mixing) within each of the 96-wells. 2. To employ periodic measurements of volume and solute flux with the same crossflow to test, screen and scale-up the best performing graft polymerized membranes using single-protein filtration and 1 relevant biotechnology feed (E. coli broth). The proposed study addresses a pressing need in the biotechnology, food, beverage, drinking water purification, wastewater treatment and bio-fuel industries for new low bio-fouling synthetic membranes. Like personalized medicine, particularized membranes for different applications can improve efficiency, and reduce costs and energy requirements. The work will promote discovery by offering previously untested novel membrane materials that exhibit low fouling, and will present a scalable HTP-PGP method for membrane manufacturers and users. The research will advance mechanistic understanding by elucidating the major requirements for a fouling resistant membrane. Results of this research will benefit society by reducing energy consumption of biochemical processes by lowering protein/peptide fouling of synthetic membranes during bioprocessing (known to cause substantial drops in performance, sometimes approaching 80%) and hence lowering operating pressures. The project will promote training and learning by involving undergraduate science and engineering majors through the Rensselaer Undergraduate Research Program and by involving high school seniors through the Questar program. Female and minority students will again be recruited to broaden participation of underrepresented groups, exposing students to modern high throughput technology, combinatorial chemistry, interfacial science, analytical chemistry and bioprocessing.
EAGER Grant申请涉及完全不同的膜合成和测试方法,应用新的专业知识(高通量平台(HTP)修饰方法与光诱导接枝聚合(PGP)(HTP-PGP)方法,表面搅拌和蛋白质筛分测量),并采用新的跨学科观点(结合聚合物化学和流体力学的知识)。在过去的35年里,由于努力、费用和时间的原因,很少有聚合物用于膜过滤生产。开发了一种新颖、快速、高效和可重复的高通量平台(HTP)光诱导接枝聚合(PGP)改性方法(HTP-PGP方法),该方法允许从66个功能化表面中合成和选择最抗蛋白质污染的聚合物用于膜分离。然而,这种新的HTP-PGP方法不容易扩展,需要包括混合和蛋白质筛选才能真正有用和可预测。这种快速、高效、可重复的HTP-PGP方法对材料科学和膜技术的高通量合成、筛选和选择做出了重大贡献。HTP-PGP选择了先前报道的抗蛋白质表面化学,发现了几个新的单体,并给出了可重复的结果。然而,为了使HTP-PGP真正用于基础研究并可扩展用于工业应用,它还应该包括具有渗透体积和溶质(筛分)通量的时间依赖性跟踪的交叉流。在这项研究中,HTP-PGP将被改造,以便它可以在可扩展的条件下从数百种功能化表面中评估和选择最佳聚合物;并分析接枝机理,以了解未来膜分离表面的设计。以17年来的膜表面改性研究成果为基础,以HTP-PGP方法为出发点,提出了96孔膜结构的两个具体研究目标:1.在96个威尔斯井中的每一个井内实施并模拟横流(混合)。2.采用相同交叉流的体积和溶质通量的定期测量,以测试、筛选和放大使用单蛋白过滤和1个相关生物技术进料的最佳性能接枝聚合膜(E.大肠杆菌肉汤)。这项研究解决了生物技术、食品、饮料、饮用水净化、废水处理和生物燃料行业对新型低生物污染合成膜的迫切需求。与个性化医疗一样,用于不同应用的特殊膜可以提高效率,降低成本和能源需求。这项工作将通过提供以前未经测试的新型膜材料来促进发现,这些材料表现出低污染,并将为膜制造商和用户提供可扩展的HTP-PGP方法。该研究将通过阐明抗污染膜的主要要求来推进机理理解。这项研究的结果将有利于社会,通过降低生物处理过程中合成膜的蛋白质/肽污染(已知会导致性能大幅下降,有时接近80%),从而降低操作压力,从而减少生物化学过程的能耗。该项目将促进培训和学习,通过伦斯勒大学本科研究计划让本科科学和工程专业的学生参与,并通过Questar计划让高中高年级学生参与。将再次招募女性和少数民族学生,以扩大代表性不足的群体的参与,让学生接触现代高通量技术,组合化学,界面科学,分析化学和生物加工。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Georges Belfort其他文献
Interactions between polycationic and polyanionic layers: Changes in rigidity, charge and adsorption kinetics
- DOI:
10.1016/j.snb.2008.10.063 - 发表时间:
2009-02-02 - 期刊:
- 影响因子:
- 作者:
Amit K. Dutta;Georges Belfort - 通讯作者:
Georges Belfort
Insight into the Lytic Mechanism of Antimicrobial Piscidin 1 and 3 using QCM-D
- DOI:
10.1016/j.bpj.2012.11.3341 - 发表时间:
2013-01-29 - 期刊:
- 影响因子:
- 作者:
Mirco Sorci;Keith Bradley;Georges Belfort;Myriam L. Cotten - 通讯作者:
Myriam L. Cotten
An in Silico Investigation of Amyloid Beta with a Focus on N-Terminus: from Structure to Amyloid Inhibitor Design
- DOI:
10.1016/j.bpj.2017.11.3177 - 发表时间:
2018-02-02 - 期刊:
- 影响因子:
- 作者:
Payel Das;Srirupa Chakrabarty;Anita Chacko;Brian Murray;Georges Belfort - 通讯作者:
Georges Belfort
An electrical analogue for electrodialysis
- DOI:
10.1016/s0011-9164(00)80104-6 - 发表时间:
1968-01-01 - 期刊:
- 影响因子:
- 作者:
Georges Belfort;G.A. Guter - 通讯作者:
G.A. Guter
Paucity of Amyloid Nuclei Defy Isolation and Toxicity Evaluation
- DOI:
10.1016/j.bpj.2010.12.1305 - 发表时间:
2011-02-02 - 期刊:
- 影响因子:
- 作者:
Mirco Sorci;Whitney Silkworth;Timothy Gehan;Georges Belfort - 通讯作者:
Georges Belfort
Georges Belfort的其他文献
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{{ truncateString('Georges Belfort', 18)}}的其他基金
EAGER: Chiral Membranes for Protein Resistance
EAGER:用于蛋白质抗性的手性膜
- 批准号:
1546589 - 财政年份:2015
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
EAGER: Interfacial disruption of supported lipid bilayers by invading peptides
EAGER:入侵肽对支持的脂质双层的界面破坏
- 批准号:
1250071 - 财政年份:2012
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
Enhanced Performance Membranes by High Throughput Modification
通过高通量改性增强膜性能
- 批准号:
0730449 - 财政年份:2007
- 资助金额:
$ 10万 - 项目类别:
Continuing Grant
NIRT:Intein Proteins as Nanoswitches for Biotechnology:Linking Molecular Modeling with Biophysical and Genetic Methods
NIRT:内含肽作为生物技术的纳米开关:将分子建模与生物物理和遗传学方法联系起来
- 批准号:
0304055 - 财政年份:2003
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
Photoinduced Grafting of Filtration Membranes: Principles and Applications
过滤膜的光诱导接枝:原理与应用
- 批准号:
0094765 - 财政年份:2001
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
SGER:Surface Molecular Imprinting of Synthetic Membranes
SGER:合成膜的表面分子印迹
- 批准号:
0087053 - 财政年份:2000
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
Travel Support for Faculty and Graduate Students to Attend the Gordon Research Conference entitled,"Membranes:Materials and Processes", Andover,New Hampshire, August 3rd-8th, 1997
为教师和研究生提供旅行支持,以参加题为“膜:材料和工艺”的戈登研究会议,新罕布什尔州安多弗,1997 年 8 月 3 日至 8 日
- 批准号:
9711081 - 财政年份:1997
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
Surface Modification of Polymeric Membranes for Low Protein Fouling
聚合物膜表面改性以降低蛋白质污染
- 批准号:
9400610 - 财政年份:1995
- 资助金额:
$ 10万 - 项目类别:
Continuing Grant
Reactive Membranes Containing Catalytic Antibodies
含有催化抗体的反应膜
- 批准号:
9406289 - 财政年份:1994
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
International Travel Support Grant: International Congress of Membranes 1993, Heidelberg, Germany 1993.
国际旅行支持补助金:1993 年国际膜大会,德国海德堡,1993 年。
- 批准号:
9312527 - 财政年份:1993
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
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