SGER:Surface Molecular Imprinting of Synthetic Membranes

SGER：合成膜的表面分子印迹

• 批准号: 0087053
• 负责人: Georges Belfort
• 金额: $ 4.99万
• 依托单位: Rensselaer Polytechnic Institute
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-15 至 2002-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0087053&HistoricalAwards=false
• 关键词: SGER; Surface; Molecular; Imprinting; Synthetic

CTS-0087053Georges BelfortRensselaer Polytechnic InstituteSGER: Surface Molecular Imprinting of Synthetic Membranes ABSTRACT The goal of this one-year "Small Grant for Exploratory Research" (SGER) is to evaluate two promising methods of molecular imprinting to produce selective molecular-recognition membranes. The expected advantages of the new methods are lower cost, an increased number of accessible imprint sites, significantly faster binding with improved mass transfer rates and reduced tailing, and applicability in aqueous environments. With two photooxidation approaches - surface template and emulsion polymerization - the approach is to prepare, characterize, and test molecular-imprinted synthetic polymeric membranes. First, for surface template polymerization, molecular-imprinted poly(ether sulfone) (PES) membranes are produced using Rensselaer Polytechnic Institute's patented photooxidation process. Since PES is intrinsically photoactive, a photoinitiator is not required, thus reducing the cost, duration and complexity of the process significantly. PES is also one of the most widely used polymers for membranes and is amenable to surface modification in aqueous environments. Second, for emulsion polymerization, after casting of water-in-oil emulsions as a thin film onto flat surfaces and onto microporous synthetic membranes, the oil phase is polymerized around the imprint and functional molecules using UV radiation. Finally, in both cases, the water and templates are removed by microwave heating, which opens up pores and leaves imprinted cavities in a two-dimensional film. The nature and significance of the potential impact of this work, should it succeed, can be summarized as follows. In traditional affinity-separation methods the active functionality must be synthesized and then attached to a support matrix. Fabricating the functionalized surface in situ can eliminate a number of processing steps. Both surface-template and emulsion polymerization as applied here have the potential to be simple, scalable, and inexpensive. Also, the resulting thin membranes could effectively compete with more common adsorption affinity methods to accomplish difficult separations.

合成膜的表面分子印迹摘要这项为期一年的“探索性研究小额资助”（SGER）的目标是评估两种有前途的分子印迹方法，以制备选择性分子识别膜。 新方法的预期优点是成本较低，可访问的压印位点的数量增加，显著更快的结合，提高传质速率和减少拖尾，以及在水性环境中的适用性。 通过两种光氧化方法-表面模板和乳液聚合-该方法是制备，表征和测试分子印迹合成聚合物膜。 首先，对于表面模板聚合，使用伦斯勒理工学院的专利光氧化工艺生产分子印迹聚醚砜（PES）膜。 由于PES本身具有光活性，因此不需要光引发剂，从而显著降低了工艺的成本、持续时间和复杂性。 PES也是用于膜的最广泛使用的聚合物之一，并且适合于在水性环境中进行表面改性。 第二，对于乳液聚合，在将油包水乳液作为薄膜流延到平坦表面上和微孔合成膜上之后，使用UV辐射使油相在印记和功能分子周围聚合。 最后，在这两种情况下，水和模板通过微波加热去除，这打开了孔隙，并在二维薄膜中留下了印迹空腔。 如果这项工作取得成功，其潜在影响的性质和意义可概述如下。在传统的亲和分离方法中，活性官能度必须合成，然后连接到支持基质上。 原位制造功能化表面可以消除许多加工步骤。 这里应用的表面模板和乳液聚合都具有简单、可扩展和廉价的潜力。 此外，所得到的薄膜可以有效地与更常见的吸附亲和方法竞争，以实现困难的分离。