International Postdoctoral Fellows Program: Development and Evolution of Crustacean Limbs

9407753威廉姆斯该奖项是根据国际初级研究员和博士后研究员计划颁发的，该计划使美国科学家和工程师能够在国外公认的卓越研究中心进行为期3至12个月的研究。该项目的奖项提供了联合研究的机会，并提供了使用国外独特或互补的设施、专业知识和实验条件的机会。该奖项将支持特里·A·威廉姆斯博士为期12个月的博士后访问，与维也纳大学的格德·B·穆勒博士合作研究甲壳类肢体的发育和进化。人们主要通过比较脊椎动物肢体发育的细胞机制和解剖模式分子在早期果蝇胚胎学中的作用来探索肢体形态发育和进化之间的关系。威廉姆斯博士建议通过研究甲壳类肢体发育来连接这两种方法。人们对节肢动物肢体形成的细胞机制知之甚少。在果蝇身上发现的许多图案可能是这种动物所独有的，这种动物在形态上经历了根本性的变化，在变态过程中，成年肢体由小袋上皮细胞发育而来。她将通过直接比较不同甲壳类肢体形态形成和增殖所涉及的细胞机制来寻找肢体发育的潜在主题。***

9407753 Williams This award is under the International Junior Investigator and Postdoctoral Fellows Program, which enables U.S. scientists and engineers to conduct three to twelve months of research abroad at research centers of proven excellence. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad. This award will support a twelve-month postdoctoral research visit by Dr. Terri A. Williams to work with Dr. Gerd B. Muller at the University of Vienna on the development and evolution of crustacean limbs. The relationship between the development and evolution of limb morphology has been explored mostly by comparing cellular mechanisms responsible for generating vertebrate limbs and by dissecting the role of patterning molecules in early Drosophila embryology. Dr. Williams proposes to bridge these two approaches by examining crustacean limb development. Little is known about the cellular mechanisms that form limbs in arthropods. Much of the patterning found in Drosophila may be unique to an animal that undergoes radical change in form and during metamorphosis develops adult limbs from small pockets of epithelial cells. She will look for underlying themes of limb development by directly comparing the cellular mechanisms involved in the formation and proliferation of different crustacean limb morphologies. ***