Chemistry of Transition Metal/Main Group Element Compounds

John Gladysz博士，犹他大学化学系，在无机、生物无机和有机金属化学项目的支持下，开发稀土的有机金属化学，为不对称合成提供新的方法，并提供仅含碳原子的长线性链的途径。在这些项目中的第一个项目中，手性硫酰化铼化合物的高度非对映选择性2,3标志位重排将用于高对映体纯度的硫衍生物。在第二部分中，乙炔片段，其中一端连接到有机铼部分，将被氧化偶联形成线性碳链，其长度为4、8、9和16个原子。研究各种反应的机理和碳链内未配对电子的离域。许多分子以两种不相同的镜像形式存在（类似于右手手套和左手手套）。许多生物学上重要的分子都是这种类型的，通常这两种镜像形式具有非常不同的性质。因此，选择性形成单一形式的能力对制药和农业等行业非常重要。本项目将开发一种新的方法来完成一些重要的含硫化合物的高选择性合成。在研究的第二部分，将制备仅由碳原子组成的长链。这些分子之所以引起人们的兴趣，是因为它们可能构成导电、线状分子的基础。

9408980 Gladysz Univ. of Utah Dr. John Gladysz, Chemistry Department, University of Utah, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program to develop the organometallic chemistry of Re to provide new methods of asymmetric synthesis and routes to long , linear chains containing only carbon atoms. In the first of these projects a highly diastereoselective 2,3 sigmatropic rearrangement of chiral rhenium sulfur-ylide compounds will be used to thio-derivatives in high enantiomeric purity. In the second portion, acetylenic fragments, in which one end is attached to an organorhenium moiety, will be oxidatively coupled to form linear carbon chains which are 4, 8, 9, and 16 atoms long. The mechanisms of the various reactions and delocalization of unpaired electrons within the carbon chains will be studied. Many molecules exist in two mirror image forms which are not the same (similar to right and left handed gloves). Many biologically important molecules are of this type and often the two mirror image form have very different properties. Consequently, the ability to selectively form a single form is of great importance to, e.g., the pharmaceutical and agrichemical industries. In this project a new method of accomplishing some highly selective syntheses of important sulfur containing compounds will be developed. In a second part of the study long chains of composed only of carbon atoms will be prepared. These are of interest because of they may form the basis of electrically conducting, wire-like molecules.