Chemistry of Transition Metal/Main Group Element Compounds

9408980 Gladysz University of犹他州犹他州大学化学系John Gladysz博士得到无机、生物无机和有机物化学计划的支持，致力于开发Re的有机金属化学，以提供不对称合成的新方法和仅含碳原子的长直链路线。在第一个项目中，手性硫叶立德化合物的高度非对映选择性的2，3 σ转移重排将用于高对映体纯度的硫代衍生物。在第二部分中，其中一端连接到有机铼部分的炔属片段将氧化偶联以形成4、8、9和16个原子长的直链碳链。将研究各种反应的机制和碳链内未成对电子的离域。 许多分子以两种不同的镜像形式存在（类似于右手和左手手套）。许多生物学上重要的分子都是这种类型，并且通常两种镜像形式具有非常不同的性质。因此，选择性地形成单一形式的能力对于例如，制药和农业化学工业。本项目将开发一种高选择性合成重要含硫化合物的新方法。在研究的第二部分中，将制备仅由碳原子组成的长链。这些是感兴趣的，因为它们可能形成导电的线状分子的基础。

9408980 Gladysz Univ. of Utah Dr. John Gladysz, Chemistry Department, University of Utah, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program to develop the organometallic chemistry of Re to provide new methods of asymmetric synthesis and routes to long , linear chains containing only carbon atoms. In the first of these projects a highly diastereoselective 2,3 sigmatropic rearrangement of chiral rhenium sulfur-ylide compounds will be used to thio-derivatives in high enantiomeric purity. In the second portion, acetylenic fragments, in which one end is attached to an organorhenium moiety, will be oxidatively coupled to form linear carbon chains which are 4, 8, 9, and 16 atoms long. The mechanisms of the various reactions and delocalization of unpaired electrons within the carbon chains will be studied. Many molecules exist in two mirror image forms which are not the same (similar to right and left handed gloves). Many biologically important molecules are of this type and often the two mirror image form have very different properties. Consequently, the ability to selectively form a single form is of great importance to, e.g., the pharmaceutical and agrichemical industries. In this project a new method of accomplishing some highly selective syntheses of important sulfur containing compounds will be developed. In a second part of the study long chains of composed only of carbon atoms will be prepared. These are of interest because of they may form the basis of electrically conducting, wire-like molecules.