Functional Analysis of a Brain-Specific Receptor Kinase

脑特异性受体激酶的功能分析

• 批准号: 9409930
• 负责人: Renping Zhou
• 金额: $ 26.4万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 1997-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9409930&HistoricalAwards=false
• 关键词: Functional; Analysis; Brain; Specific; Receptor

During the development of the nervous system, neurons undergo a number of processes, including proliferation and differentiation. The purpose of this research is to study the role of a growth factor receptor-like molecule (brain specific kinase, Bsk) in neuronal differentiation. Growth factors and their receptors are known to induce neuronal differentiation and support the survival of neurons, and Bsk has been shown to be associated with neurons in the limbic system of the brain during development. The studies will, first, investigate the timing of the production of Bsk by neurons in the limbic system, and then will attempt to modify the timing of its production by introducing into limbic system neurons an altered Bsk gene. The results of these studies will further our understanding of the development of the limbic system as well as the role of growth factors in neural development.

在神经系统的发育过程中，神经元经历了包括增殖和分化在内的一系列过程。本研究的目的是研究生长因子受体样分子（脑特异性激酶，Bsk）在神经元分化中的作用。已知生长因子及其受体可诱导神经元分化并支持神经元的存活，而Bsk已被证明与发育过程中大脑边缘系统中的神经元有关。这些研究将首先调查边缘系统神经元产生Bsk的时间，然后将尝试通过将改变的Bsk基因引入边缘系统神经元来改变其产生的时间。这些研究的结果将进一步加深我们对边缘系统的发育以及生长因子在神经发育中的作用的理解。