Modernization of Advanced Instrumentation Area; Renovation of Research Space and Greenhouse

卫斯理大学是学术研究基础设施计划的资金接受者，用于修复，翻新和现代化化学和生命科学研究和研究培训的关键设施。具体而言，将一个大型死亡光谱研究实验室现代化改造为多功能先进仪器设施，并对选定的研究实验室和温室进行改造。受影响的实验室位于连接的Hall-Atwater和Shanklin建筑的地下室和地面层，这些建筑构成了卫斯理科学中心的一部分。先进的仪器设备将支持物理化学、生物化学和分子生物物理学方面的研究。将受益于这些改造的研究项目包括：核酸结构和碱基对打开事件的核磁共振研究，受损DNA的核磁共振研究，DNA和蛋白质-DNA相互作用的分子动力学，全合成中的化学中间体研究，电化学机制和合成研究，金属蛋白和模型复合物的EPR研究。与此同时，与植物遗传学和进化生物学领域的教师发展相结合，生物系的温室和相关研究空间将进行升级和翻新，以支持植物表型可塑性的生态物理和进化研究。翻新将包括重新配置空间，升级机械、电气、环境控制和管道系统；在研究实验室安装工作台和固定橱柜。温室的改进将包括重新铺设混凝土地板，更换失效的排气马达、执行器和垫冷却器；清洁及重新密封窗户玻璃；提供应急电源，准备和设备区。翻新将产生几个直接的影响，包括在一个集中的地点整合先进的仪器，这将创造一个研究活动的场所。翻新后的实验室将为教师、研究生和本科生进行研究提供一个现代化的环境，并将促进跨学科研究人员之间的协作互动。

Wesleyan University is the recipient of funds from the Academic Research Infrastructure Program to repair, renovate and modernize key facilities for research and research training in chemistry and the life sciences. Specifically, a large moribund spectroscopy research laboratory will be modernized into a multipurpose advanced instrumentation facility, and selected research laboratories and a greenhouse will be renovated. The effected laboratories are located in the basement and ground floors of the connected Hall-Atwater and Shanklin buildings that comprise part of the Wesleyan Science Center. The advanced instrumentation facility will support research initiatives in physical chemistry, biochemistry and molecular biophysics. Investigative projects that will benefit from the renovations include: NMR studies of the structure and base pair opening events in nucleic acids and NMR studies of damaged DNA, molecular dynamics of DNA and protein-DNA interactions, studies of chemical intermediates in total synthesis, electrochemical mechanistic and synthetic studies, and EPR studies of metalloproteins and model complexes. In a parallel initiative, in conjunction with faculty development in the area of plant genetics and evolutionary biology, the greenhouse and related research space in the Biology Department will be upgraded and renovated to support research in ecophysical and evolutionary studies of plant phenotypic plasticity. Renovations will involve reconfiguring space, upgrading mechanical, electrical, environmental control, and plumbing systems; and installing benches and fixed cabinetry in research laboratories. The improvements for the greenhouse will consist of resurfacing concrete floors, replacing defunct vent motors, actuators, and pad coolers; cleaning and re-sealing the glazing of windows; providing emergency power, and prep and equipment areas. The renovations will have several immediate implications including the consolidation of advanced instruments in a centralized location that will create a locus of research activity. The renovated laboratories will provide a modern environment for faculty, graduate and undergraduate students to conduct research, and will foster collaborative interactions among research personnel across disciplinary lines.