Parameter Estimation of Neuronal Systems by Linear Association, U.S.-Egypt Cooperative Research

9417206杜兰德描述：该项目支持俄亥俄州克利夫兰凯斯西储大学生物医学工程系的Dominique Durand博士和埃及开罗大学生物医学工程系的Bassel Tawfik博士之间的合作。该项目涉及一种新的参数估计方法，特别是在生物系统的环境中。这种利用线性联想记忆(LAM)的方法已被应用于神经元电参数的估计。初步结果表明，LAM所得到的神经估计问题的参数估计总是落在“真”解的邻域内。本项目的目标是：评估LAM方法对局部极小问题的免疫程度；通过首先使用递归算法来扩大其范围来进一步发展该方法；添加非线性项以提高精度；最后使用Durand博士实验室收集的数据将该技术应用于海马区颗粒细胞的神经元参数估计。范围：该项目将使两名调查员及其各自部门能够开展合作活动，其中数据收集将在CWRU进行，数据分析将在开罗大学进行，对结果的最终审查和评价将由两名首席调查员共同负责。该项目很好地符合国际项目部的标准。***

9417206 Durand Description: This project supports cooperation between Dr. Dominique Durand, Biomedical Engineering Department at Case Western Reserve University in Cleveland, OH, and Dr. Bassel Tawfik, Biomedical Engineering Department at Cairo University in Egypt. The project deals with a new method for parameter estimation, especially in the environment of biological systems. The method, which utilizes Linear Associative Memories (LAM) has been applied to the estimation of electronic parameters of nerve cells. The initial results indicate that parameter estimates for a neural estimation problems obtained by LAM, always fall within the neighborhood of the "true" solution. The objectives of this project are: to assess the degree of immunity of the LAM methods to the problem of local minima; to develop the method further by first using a recursive algorithm to improve its range; to add non-linear terms to improve the accuracy; and finally to apply this technique to the estimation of neuronal parameters of granule cells in the hippocampus using data collected in Dr. Durand laboratory. Scope: This project will allow a cooperative activity between the two investigators and their respective departments where data collection will be done at CWRU while data analysis will be performed at Cairo University, and where the final examination and evaluation of the results will be the mutual responsibility of the two principal investigators. The project meets the criteria of the Division of International Programs well. ***