RIMI: Signal Transduction Mechanisms

9450476提议的研究涉及几个项目，其共同主题是关注信号转导的细胞和分子机制，使用各种细胞类型作为实验模型系统。第一个项目将测试一个假设，即生理上相关的改变发生在g蛋白或其亚基的细胞水平上。第二个项目将研究外周苯二氮卓受体在肺泡二型肺细胞中的生理功能。第三个项目将研究胞质钙通量对半乳糖苷结合蛋白的分泌和细胞表面表达的调控和分泌。

9450476 The proposed research involves several projects with a common theme focusing on cellular and molecular mechanisms of signal transduction using a variety of cell types as experimental model systems. The first project will test the hypothesis that physiologically relevant alterations occur in the cellular levels of G-proteins or their subunits. The second project will investigate the physiological functions of peripheral benzodiazepine receptors in alveolar type two neumocytes. The third project will study the regulation and secretion of secretion and cell surface expression of galactoside binding proteins by cytosolic calcium fluxes.