U.S,-Czech Genetics Research on the Structure and Evolution of the Rhodobacter Capsulatus Genome

9506881 Haselkorn芝加哥大学的Robert Haselkorn博士和捷克分子遗传学研究所的Vaclav Pace博士开展的这项美国-捷克联合研究项目的目标是克隆和测序三种胶囊红杆菌菌株的特定染色体片段。这种细菌是紫色的，不进行光合作用，在类胡萝卜素的生物合成、光化学反应中心和固氮研究中很有用。研究人员将表征和克隆的片段包含了大规模染色体重排和变化所产生的连接。这种合作努力应该会产生关于细菌核苷酸序列的新知识，并可能有助于确定这些重排的机制。这些结果将加深我们对基因组可塑性和进化的基本理解。这一微生物遗传学项目通过使美国和东欧的顶尖专家能够将互补的人才结合在一起，并在相互感兴趣和能力很强的领域汇集研究资源，从而实现了促进科学知识的计划目标。***

9506881 Haselkorn The objective of this U.S.-Czech joint research project between Dr. Robert Haselkorn of the University of Chicago and Dr. Vaclav Paces of the Czech Institute of Molecular Genetics is to clone and sequence particular fragments of the chromosome from three strains of the bacterium Rhodobacter capsulatus. This bacterium is purple and non-photosynthetic and useful in studies of carotenoid biosynthesis, photochemical reactions centers, and nitrogen fixation. The fragments to be characterized and cloned by the researchers contain the junctions created by large-scale chromosomal rearrangements and changes. The collaborative effort should yield new knowledge about the bacterium's nucleotide sequences and may help determine the mechanisms of these rearrangements. Results would further our basic understanding of genome plasticity and evolution. This project in microbial genetics fulfills the program objective of advancing scientific knowledge by enabling leading experts in the United States and Eastern Europe to combine complementary talents and pool research resources in areas of strong mutual interest and competence. ***