U.S,-Czech Genetics Research on the Structure and Evolution of the Rhodobacter Capsulatus Genome

美国、捷克关于荚膜红杆菌基因组结构和进化的遗传学研究

• 批准号: 9506881
• 负责人: Robert Haselkorn
• 金额: $ 8.04万
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9506881&HistoricalAwards=false
• 关键词: U.S; Czech; Genetics; Research; Structure

9506881 Haselkorn The objective of this U.S.-Czech joint research project between Dr. Robert Haselkorn of the University of Chicago and Dr. Vaclav Paces of the Czech Institute of Molecular Genetics is to clone and sequence particular fragments of the chromosome from three strains of the bacterium Rhodobacter capsulatus. This bacterium is purple and non-photosynthetic and useful in studies of carotenoid biosynthesis, photochemical reactions centers, and nitrogen fixation. The fragments to be characterized and cloned by the researchers contain the junctions created by large-scale chromosomal rearrangements and changes. The collaborative effort should yield new knowledge about the bacterium's nucleotide sequences and may help determine the mechanisms of these rearrangements. Results would further our basic understanding of genome plasticity and evolution. This project in microbial genetics fulfills the program objective of advancing scientific knowledge by enabling leading experts in the United States and Eastern Europe to combine complementary talents and pool research resources in areas of strong mutual interest and competence. ***

这个由芝加哥大学的Robert Haselkorn博士和捷克分子遗传学研究所的Vaclav Paces博士共同开展的美国-捷克联合研究项目的目标是克隆三株荚膜红杆菌的染色体特定片段并对其进行测序。这种细菌呈紫色，不进行光合作用，在类胡萝卜素生物合成、光化学反应中心和固氮研究中很有用。研究人员将鉴定和克隆的片段包含大规模染色体重排和变化产生的连接。合作的努力将产生关于细菌核苷酸序列的新知识，并可能有助于确定这些重排的机制。研究结果将进一步加深我们对基因组可塑性和进化的基本认识。这个微生物遗传学项目通过使美国和东欧的领先专家在共同感兴趣和能力强的领域结合互补的人才和集中研究资源，实现了推进科学知识的计划目标。＊＊＊