Development of a Catalytic, Asymmetric {2+2} Cycloaddition for the Synthesis of 2-Oxetanones

用于合成 2-氧杂环丁酮的催化不对称 {2 2} 环加成反应的开发

• 批准号: 9510566
• 负责人: Daniel Romo
• 金额: $ 1.8万
• 依托单位: Texas A&M Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 1997-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9510566&HistoricalAwards=false
• 关键词: Development; Catalytic; Asymmetric; 2+2; Cycloaddition

This RPG in the Organic Synthesis Program to Professor Romo of Texas A&M University will be used to elaborate the chiral catalysis of 2 + 2 cycloadditions for the synthesis of 2-oxetanones. These compounds which are better known as beta lactones are important moieties in many physiologically active chemical compounds. Moreover, these types of monomers are used in polymerization reactions and in organic synthetic strategies. The control of catalytic processes in such a way as to yield chiral products is an important goal. This proposal has this goal and appears to be an excellent opportunity to find new ways of synthesizing physiologically active compounds. These results will be useful in the medicinal chemistry and polymer fields.

德克萨斯州农工大学罗莫教授有机合成项目中的这个RPG 大学将用于阐述手性催化2 + 2 用于合成2-氧杂环丁酮的环加成反应。这些化合物， 更好地称为β内酯，在许多 生理活性化合物。此外，这些类型的 单体用于聚合反应和有机合成中， 战略布局 控制催化过程，以产生手性 产品是一个重要的目标。该提案具有这一目标，似乎 是一个很好的机会去寻找新的合成方法 生理活性化合物。这些结果将有助于 药物化学和聚合物领域。