Development of a Catalytic, Asymmetric {2+2} Cycloaddition for the Synthesis of 2-Oxetanones

德克萨斯a&m大学Romo教授的有机合成程序中的RPG将用于阐述2 + 2环加成的手性催化合成2-氧乙酮。这些被称为内酯的化合物是许多具有生理活性的化合物的重要组成部分。此外，这些类型的单体用于聚合反应和有机合成策略。控制催化过程以产生手性产物是一个重要的目标。这个提议有这个目标，似乎是一个极好的机会，找到新的方法来合成生理活性化合物。这些结果在药物化学和高分子领域具有重要的应用价值。

This RPG in the Organic Synthesis Program to Professor Romo of Texas A&M University will be used to elaborate the chiral catalysis of 2 + 2 cycloadditions for the synthesis of 2-oxetanones. These compounds which are better known as beta lactones are important moieties in many physiologically active chemical compounds. Moreover, these types of monomers are used in polymerization reactions and in organic synthetic strategies. The control of catalytic processes in such a way as to yield chiral products is an important goal. This proposal has this goal and appears to be an excellent opportunity to find new ways of synthesizing physiologically active compounds. These results will be useful in the medicinal chemistry and polymer fields.