Asymmetric Synthesis and Novel Transformations of 2-Oxetanones

德克萨斯农工大学化学系的Daniel Romo教授得到了有机和高分子化学计划的支持，他通过亲核催化的烯酮和醛的羟醛-内酰化反应(NCAL)开发了简明而实用的β-内酯的对映选择性合成。将探索这些β-内酯形成各种杂环结构的新转化。分子内NCAL反应的实用性将通过对天然产物布雷菲尔丁A的全合成和对映体选择性合成来说明。NCAL反应的机理研究将使用Reaction IR和1H NMR进行。在有机和高分子程序的支持下，Romo教授正在开发新的方法，通过这些方法可以精确控制某些高度应变的有机化合物的三维结构。这些化合物作为中间体，可以进一步转化为更复杂的产品，其中许多与药理活性化合物具有相似的结构特征。

Professor Daniel Romo in the Department of Chemistry at Texas A&M University is supported by the Organic and Macromolecular Chemistry Program for his development of concise and practical enantioselective syntheses of beta-lactones via nucleophile catalyzed aldol-lactonizations (NCALs) of ketenes and aldehydes. Novel transformations of these beta-lactones to form various heterocyclic structures will be explored. The utility of the intramolecular NCAL reaction will be illustrated by the total synthesis of a lactacystin analog and an enantioselective synthesis of the natural product, brefeldin A. Mechanistic studies on the NCAL reaction will be carried out using REACT IR and 1H NMR.With the support of the Organic and Macromolecular Program, Professor Romo is developing novel methods by which certain highly strained organic compounds can be prepared with precise control of their three-dimensional structure. These compounds serve as intermediates which can be further converted to more complex products, many of which are share similar structural features with pharmacologically active compounds.