CAREER: Asymmetric Synthesis and Novel Transformations of 2-Oxetanones; Minority Outreach/Multimedia Approaches to Understanding Organic Chemistry and Its Societal Relevance

职业：2-氧杂环丁酮的不对称合成和新颖转化；

• 批准号: 9624532
• 负责人: Daniel Romo
• 金额: $ 32.51万
• 依托单位: Texas A&M Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9624532&HistoricalAwards=false
• 关键词: CAREER; Asymmetric; Synthesis; Novel; Transformations

This research focuses on the preparation of beta-lactones by the development of Lewis acid mediated (2+2) cycloaddition chemistry and tandem aldol/lactonization methodology. New transformations of beta-lactones including intramolecular allylsilane additions and ferric chloride mediated tandem debenzylation/transacylation will be probed. The educational plan focuses on the development of a `transition` course for first year graduate students, including minorities, minority outreach to local high schools and development of multimedia presentations for use in the teaching of organic chemistry. With this CAREER award, the Synthetic Organic Program is supporting the research and educational activities of Dr. Daniel Romo of the Department of Chemistry at Texas A&M University. Professor Romo will focus his research effort on the asymmetric synthesis of a class of compounds known as beta-lactones. These compounds serve as useful intermediates in organic synthesis, are utilized as polymerization substrates and the basic structural unit appears in a variety of physiologically active natural products. The educational plan will focus on the development of a `transition` course for educationally disadvantaged first year graduate students and the development of multimedia presentations related to organic chemistry

本研究的重点是β-内酯的制备， 发展了刘易斯酸介导的（2 + 2）环加成化学， 串联羟醛/内酯化方法。 新的转型 β-内酯，包括分子内烯丙基硅烷加成和三价铁 将探测氯化物介导的串联脱苄基/转酰作用。 教育计划的重点是制定"过渡"课程 为一年级研究生，包括少数群体，少数群体外联 为当地的高中和开发多媒体演示文稿， 在有机化学教学中的应用。 有了这个职业奖， 合成有机计划是支持研究和教育 德州农工大学化学系的丹尼尔罗莫博士& 大学 罗莫教授将把他的研究重点放在 不对称合成一类称为β-内酯的化合物。 这些化合物在有机合成中用作有用的中间体， 用作聚合底物和基本结构单元， 出现在各种生理活性天然产物中。 的 教育计划将侧重于开发"过渡"课程 为教育上处于不利地位的一年级研究生和 开发与有机化学相关的多媒体演示文稿