Novel Asymmetric Routes to 2-Oxetanones and Their Application

2-氧杂环丁酮的新型不对称路线及其应用

• 批准号: 0416260
• 负责人: Daniel Romo
• 金额: $ 39万
• 依托单位: Texas A&M Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0416260&HistoricalAwards=false
• 关键词: Novel; Asymmetric; Routes; Oxetanones; Their

The focus of this research involves the use of beta lactones in synthesis. Several applications of the intramolecular nucleophile catalyzed aldol-lactonization (NCAL) process will be highlighted. The NCAL process merges catalytic, asymmetric beta-lactone synthesis with carbocycle and heterocycle synthesis. Target molecules will include spongiolactone, a marine metabolite, and belactosin, an antitumor, Streptomyces metabolite. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Daniel Romo in the Department of Chemistry at Texas A&M University. Dr. Romo will focus his work on developing concise, practical enantioselective routes to beta-lactones (2-oxetanones) involving nucleophilic catalysis and the application of these methods to natural and unnatural product synthesis. The research could have a broader impact on the pharmaceutical industry and the project will be an excellent arena for the training of undergraduate and graduate students, many of whom come from the underrepresented minority population in Texas.

这项研究的重点涉及β内酯在合成中的应用。 分子内亲核试剂催化的羟醛内酯化（NCAL）过程的几个应用将突出显示。 NCAL工艺将催化、不对称β-内酯合成与碳环和杂环合成相结合。 靶分子将包括海绵内酯（一种海洋代谢物）和belactosin（一种抗肿瘤链霉菌代谢物）。有了这个奖项，有机和高分子化学计划正在支持博士丹尼尔罗莫在化学系在得克萨斯州农工大学的研究。 Romo博士将专注于开发简明实用的β-内酯（2-氧杂环丁酮）对映选择性路线，包括亲核催化以及这些方法在天然和非天然产物合成中的应用。 这项研究可能会对制药业产生更广泛的影响，该项目将成为培养本科生和研究生的绝佳竞技场，其中许多人来自德克萨斯州代表性不足的少数民族。