Novel Asymmetric Routes to 2-Oxetanones and Their Application

本研究的重点是在合成中使用-内酯。重点介绍了分子内亲核试剂催化醛缩内酯化（NCAL）过程的几种应用。NCAL工艺将催化、不对称β -内酯合成与碳环和杂环合成相结合。目标分子将包括海绵内酯（一种海洋代谢物）和乳杆菌素（一种抗肿瘤的链霉菌代谢物）。通过这个奖项，有机和大分子化学项目支持了德克萨斯农工大学化学系Daniel Romo博士的研究。Romo博士将专注于开发简洁、实用的β -内酯（2-氧内酮）的对映选择途径，包括亲核催化以及将这些方法应用于天然和非天然产物合成。这项研究可能会对制药业产生更广泛的影响，该项目将成为培养本科生和研究生的绝佳场所，其中许多学生来自德克萨斯州未被充分代表的少数民族。

The focus of this research involves the use of beta lactones in synthesis. Several applications of the intramolecular nucleophile catalyzed aldol-lactonization (NCAL) process will be highlighted. The NCAL process merges catalytic, asymmetric beta-lactone synthesis with carbocycle and heterocycle synthesis. Target molecules will include spongiolactone, a marine metabolite, and belactosin, an antitumor, Streptomyces metabolite. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Daniel Romo in the Department of Chemistry at Texas A&M University. Dr. Romo will focus his work on developing concise, practical enantioselective routes to beta-lactones (2-oxetanones) involving nucleophilic catalysis and the application of these methods to natural and unnatural product synthesis. The research could have a broader impact on the pharmaceutical industry and the project will be an excellent arena for the training of undergraduate and graduate students, many of whom come from the underrepresented minority population in Texas.